{"id":"W4388185574","doi":"10.3390/genes14112010","title":"Genome-Wide Association Analysis across Endophenotypes in Alzheimer’s Disease: Main Effects and Disease Stage-Specific Interactions","year":2023,"lang":"en","type":"article","venue":"Genes","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Common Fund; National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; NIH Office of the Director; National Human Genome Research Institute; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; U.S. National Library of Medicine; National Institute of Neurological Disorders and Stroke; IXICO; National Institute of General Medical Sciences; H. Lundbeck A/S; National Cancer Institute; Servier; Northern California Institute for Research and Education; National Institute of Mental Health; Novartis Pharmaceuticals Corporation; National Heart, Lung, and Blood Institute; BioClinica; Biogen; Pfizer; F. Hoffmann-La Roche; University of Southern California; National Institute on Drug Abuse; U.S. Department of Defense; Eli Lilly and Company; GE Healthcare; Merck; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Endophenotype; Genome-wide association study; Genetic association; SNP; Single-nucleotide polymorphism; Disease; Biology; Genetics; Alzheimer's Disease Neuroimaging Initiative; Alzheimer's disease; Medicine; Neuroscience; Gene; Cognition; Genotype; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002152733,0.0001795808,0.0003028405,0.0003753109,0.0001767412,0.00007165853,0.00006527734,0.00003747002,0.0001256998],"category_scores_gemma":[0.0002969785,0.0001622444,0.0001749596,0.001123148,0.0000468915,0.0001379457,0.00009290234,0.0001164003,0.0002157267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002036363,"about_ca_system_score_gemma":0.0001405297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007095857,"about_ca_topic_score_gemma":0.0001214179,"domain_scores_codex":[0.9983298,0.0001342817,0.0002076154,0.000408396,0.0004126348,0.0005072316],"domain_scores_gemma":[0.998242,0.0004872959,0.00007074831,0.0003140814,0.00006041505,0.0008254892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004269816,0.0002381138,0.9865659,0.00006588372,0.008271758,0.0009004086,0.0001549018,0.0001524361,0.0001154053,0.00001636494,0.0004025444,0.002689322],"study_design_scores_gemma":[0.001075873,0.00003378907,0.9935939,0.00002675799,0.002160756,3.886179e-7,0.0001351489,0.0003938308,0.00008895532,0.0001685182,0.002190544,0.0001315892],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9640116,0.03324949,0.00003287103,0.001285808,0.00008492845,0.0005892767,0.0005704573,0.0001071214,0.00006842116],"genre_scores_gemma":[0.995792,0.002254281,0.00004271547,0.0001108463,0.0001024628,0.000212061,0.001013565,0.00002604545,0.0004459921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0317804,"threshold_uncertainty_score":0.6616134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03225775831684367,"score_gpt":0.3376925345254427,"score_spread":0.305434776208599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}