{"id":"W4388185574","doi":"10.3390/genes14112010","title":"Genome-Wide Association Analysis across Endophenotypes in Alzheimer’s Disease: Main Effects and Disease Stage-Specific Interactions","year":2023,"lang":"en","type":"article","venue":"Genes","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Common Fund; National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; NIH Office of the Director; National Human Genome Research Institute; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; U.S. National Library of Medicine; National Institute of Neurological Disorders and Stroke; IXICO; National Institute of General Medical Sciences; H. Lundbeck A/S; National Cancer Institute; Servier; Northern California Institute for Research and Education; National Institute of Mental Health; Novartis Pharmaceuticals Corporation; National Heart, Lung, and Blood Institute; BioClinica; Biogen; Pfizer; F. Hoffmann-La Roche; University of Southern California; National Institute on Drug Abuse; U.S. Department of Defense; Eli Lilly and Company; GE Healthcare; Merck; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Endophenotype; Genome-wide association study; Genetic association; SNP; Single-nucleotide polymorphism; Disease; Biology; Genetics; Alzheimer's Disease Neuroimaging Initiative; Alzheimer's disease; Medicine; Neuroscience; Gene; Cognition; Genotype; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009046104,0.001253169,0.001602257,0.001907601,0.0007296399,0.00138941,0.0008832511,0.0008743736,0.001677851],"category_scores_gemma":[0.007925211,0.0004262347,0.005167086,0.002241127,0.0009660324,0.0005436668,0.001332048,0.0008674725,0.0001387487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000470777,"about_ca_system_score_gemma":0.001018621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003381163,"about_ca_topic_score_gemma":0.007074905,"domain_scores_codex":[0.9909671,0.005876214,0.0004240771,0.001747755,0.00063371,0.0003510978],"domain_scores_gemma":[0.9917434,0.005530629,0.001021508,0.001042271,0.0003187059,0.0003434763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003184589,0.00009813195,0.9486446,0.0002053135,0.01218855,0.0006943393,0.0003021449,0.0008707501,0.01261683,0.001455205,0.000313062,0.0194265],"study_design_scores_gemma":[0.0002249441,0.0006718128,0.9837013,0.00003692469,0.006285356,0.00052671,0.0001237972,0.003678963,0.001347887,0.002458694,0.0009151433,0.00002855105],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820015,0.004272414,0.01158652,0.0004304057,0.00005797571,0.00005928444,0.000690499,0.00008565265,0.0008157946],"genre_scores_gemma":[0.9936175,0.0005094287,0.005028358,0.000112137,0.00002292742,0.00007177838,0.0003239193,0.00002405141,0.0002897831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009046104,"threshold_uncertainty_score":0.04784095,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03225775831684367,"score_gpt":0.3376925345254427,"score_spread":0.305434776208599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}