{"id":"W4388190746","doi":"10.1101/2023.10.24.563889","title":"Measuring mtDNA turnover, synthesis, and supercoiling via selective bromodeoxyuridine incorporation","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; Alberta Children's Hospital; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Government of Alberta","keywords":"Mitochondrial DNA; Organelle; Mitochondrion; Biology; DNA supercoil; Computational biology; Genome; Cell biology; Molecular biology; DNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007592592,0.0006679543,0.0003953917,0.0008832176,0.0003337892,0.0005602356,0.0004974711,0.0005705917,0.00200481],"category_scores_gemma":[0.0006841906,0.0004219802,0.0002903964,0.0005471574,0.0004015193,0.0003864793,0.000373527,0.001280206,0.001593559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003955872,"about_ca_system_score_gemma":0.0002102562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004600633,"about_ca_topic_score_gemma":0.0009227932,"domain_scores_codex":[0.9992666,0.0001299688,0.00005766391,0.0002313083,0.000247028,0.00006749461],"domain_scores_gemma":[0.9992332,0.0002503338,0.0001388925,0.0001619822,0.0001511455,0.00006441807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002693391,0.00001074481,0.00008075307,0.00003210466,0.000003477298,0.0000102326,0.00001903383,0.00002799391,0.9986399,0.00009153743,0.00003827109,0.001019018],"study_design_scores_gemma":[0.000002459042,0.00003411072,0.0009495598,0.000006072608,0.000008286185,0.00004524058,0.00000984604,0.0003174147,0.9966385,0.00005346681,0.001930039,0.000004921788],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6404091,0.007673637,0.3317761,0.0003283195,0.0003544214,0.0004232595,0.005356618,0.002562409,0.01111609],"genre_scores_gemma":[0.6291312,0.006009463,0.3267161,0.0002680219,0.00008966759,0.000619095,0.008944741,0.001227802,0.02699377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00200481,"threshold_uncertainty_score":0.006706715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02351240003129413,"score_gpt":0.2154382882124837,"score_spread":0.1919258881811896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}