{"id":"W4388200481","doi":"10.1101/2023.10.23.563678","title":"Increased spontaneous Ca <sup>2+</sup> activity in Cardiac Purkinje cells after myocardial infarction; A consequence of a dramatic shift of SERCA isoforms as potential adaptation to acute ischemia?","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary; Memorial University of Newfoundland","funders":"Canadian Institutes of Health Research","keywords":"SERCA; Endoplasmic reticulum; Internal medicine; Gene isoform; Chemistry; Purkinje fibers; Intracellular; Endocrinology; Biology; Medicine; Electrophysiology; ATPase; Biochemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001052659,0.0001652976,0.0002415257,0.0001369384,0.0001134296,0.0003580693,0.0001502661,0.000233139,0.001158116],"category_scores_gemma":[0.0001365407,0.0001166225,0.0001385111,0.0001010896,0.0002382297,0.0002190046,0.0001474811,0.0002450683,0.0001859759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001431887,"about_ca_system_score_gemma":0.00006336144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002977387,"about_ca_topic_score_gemma":0.0002282835,"domain_scores_codex":[0.9999496,0.000005462644,0.000004032956,0.00001661797,0.00001116726,0.00001313583],"domain_scores_gemma":[0.9999062,0.00001213528,0.00003241764,0.00001087188,0.000009593866,0.000028801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005535109,0.00003171126,0.01384549,0.00005922341,0.00002017496,0.0008762045,0.00008809296,0.0001521493,0.9806885,0.000118177,0.00006819928,0.003498583],"study_design_scores_gemma":[0.00006341432,0.001042408,0.6441112,0.00002370626,0.00007862561,0.003706287,0.000577441,0.004295557,0.3429407,0.0006918477,0.002447948,0.00002097174],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968976,0.0009992198,0.001510309,0.0000503532,0.00001009327,0.000008141977,0.00009070536,0.00004474032,0.0003888533],"genre_scores_gemma":[0.999171,0.0002347985,0.0002231871,0.00001189367,0.000007921097,0.000008666127,0.00007608304,0.000004688987,0.0002616636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001158116,"threshold_uncertainty_score":0.003874302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007396515066527846,"score_gpt":0.2202731527888337,"score_spread":0.2128766377223058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}