{"id":"W4388201325","doi":"10.3390/cells12212526","title":"Measuring Single-Cell Calcium Dynamics Using a Myofilament-Localized Optical Biosensor in hiPSC-CMs Derived from DCM Patients","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Canadian Institutes of Health Research; Courtois Foundation","keywords":"Myofilament; Ventricle; Calcium; Cardiology; Dilated cardiomyopathy; Heart failure; Cardiomyopathy; Internal medicine; Calcium signaling; Calcium in biology; Medicine; L-type calcium channel; Stimulation; Biophysics; Chemistry; Biomedical engineering; Myocyte; Calcium channel; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001798974,0.0002464844,0.0005723825,0.0002067626,0.00008942538,0.00003047626,0.00008596875,0.0001479608,0.0000186307],"category_scores_gemma":[0.0001126044,0.0002358019,0.0001778545,0.0004485033,0.0001114492,0.00005246021,0.0001850079,0.0002244914,0.0001392908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004730638,"about_ca_system_score_gemma":0.00004927415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002077196,"about_ca_topic_score_gemma":0.00003012884,"domain_scores_codex":[0.9982054,0.00007075626,0.0003991872,0.000427543,0.0003891285,0.0005079683],"domain_scores_gemma":[0.9991737,0.0001684266,0.00007675237,0.0003155901,0.0001023622,0.0001631706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003421813,0.0004744771,0.03219958,0.0001174784,0.0001038386,0.0003801902,0.001053571,0.0001886526,0.9626979,0.000008510006,0.0003017439,0.002131888],"study_design_scores_gemma":[0.0104901,0.000295925,0.06187221,0.0006735314,0.0004733933,0.000008134705,0.00223861,0.0162918,0.9058836,0.00005662101,0.001046978,0.0006690638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958196,0.0001900101,0.0004595827,0.0001026239,0.0008000762,0.0004497009,0.00005970823,0.0001353843,0.001983287],"genre_scores_gemma":[0.9974763,0.00005113644,0.001692138,0.0001517305,0.0001502251,0.00001296881,0.0001110631,0.00005016742,0.0003042954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05681425,"threshold_uncertainty_score":0.9615721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07367099133350252,"score_gpt":0.2645061446657406,"score_spread":0.1908351533322381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}