{"id":"W4388203347","doi":"10.1200/op.2023.19.11_suppl.538","title":"Real-world comparative effectiveness and safety of pembrolizumab vs chemotherapy for previously untreated PD-L1≥50% metastatic non-small cell lung cancer.","year":2023,"lang":"en","type":"article","venue":"JCO Oncology Practice","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Pembrolizumab; Medicine; Internal medicine; Hazard ratio; Lung cancer; Cohort; Oncology; Retrospective cohort study; Chemotherapy; Confidence interval; Population; Proportional hazards model; Propensity score matching; Surgery; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001387909,0.000275285,0.001060368,0.0002201132,0.0001479715,0.00001503139,0.0001159974,0.0001387584,0.0001085177],"category_scores_gemma":[0.0001421976,0.0002358995,0.0001527907,0.0006617918,0.0002131378,0.0001715259,0.00004032594,0.000255769,0.000007023815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000549717,"about_ca_system_score_gemma":0.0009246247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002100007,"about_ca_topic_score_gemma":0.0008803864,"domain_scores_codex":[0.9979329,0.0005302309,0.0005210632,0.0004453486,0.0001714255,0.0003991044],"domain_scores_gemma":[0.9935724,0.005117518,0.0006032689,0.0002932331,0.0002993499,0.000114189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7365647,0.003177356,0.0257538,0.01094418,0.008797984,0.000258714,0.01580878,0.0002787946,0.1359522,0.000264488,0.02148239,0.0407166],"study_design_scores_gemma":[0.1283216,0.01480363,0.5362424,0.002864753,0.007237554,0.0003105547,0.004470866,0.006374931,0.08427923,0.00008575644,0.2138949,0.001113933],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9783283,0.002179469,0.0004098244,0.00429911,0.0003916643,0.005585215,0.00008878732,0.0001188857,0.00859877],"genre_scores_gemma":[0.9722938,0.01755783,0.003963271,0.00163262,0.0001668026,0.001261768,0.0001242689,0.00008685456,0.002912793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6082432,"threshold_uncertainty_score":0.9619704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03380880804976588,"score_gpt":0.3932622976676847,"score_spread":0.3594534896179188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}