{"id":"W4388211905","doi":"10.1164/rccm.202301-0067oc","title":"Blood-based Transcriptomic and Proteomic Biomarkers of Emphysema","year":2023,"lang":"en","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Chronic Obstructive Pulmonary Disease (COPD) Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"National Heart, Lung, and Blood Institute; Sunovion; GlaxoSmithKline; COPD Foundation; Genentech; AstraZeneca; Pfizer","keywords":"Medicine; Biomarker; Receiver operating characteristic; Biomarker discovery; Proteomics; Internal medicine; Oncology; Bioinformatics; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002472662,0.0007879204,0.0005274817,0.001167297,0.0002411558,0.0008755336,0.0003255975,0.0003794097,0.001622782],"category_scores_gemma":[0.004350541,0.0002041292,0.0005434619,0.0007552822,0.0003329872,0.0003587983,0.0004994139,0.0005874831,0.0003345435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002686332,"about_ca_system_score_gemma":0.0003823094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001211689,"about_ca_topic_score_gemma":0.001261167,"domain_scores_codex":[0.9993696,0.0002598835,0.00004251449,0.0001626564,0.0001176483,0.00004771402],"domain_scores_gemma":[0.9984425,0.0008852303,0.0003020759,0.0001371479,0.0001676688,0.00006540392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001360691,0.0002032481,0.9319143,0.0001434283,0.0002731816,0.0001654423,0.00008238856,0.008526785,0.02934722,0.0004788273,0.0005579596,0.02694649],"study_design_scores_gemma":[0.0001028604,0.0005872438,0.8482445,0.0001041195,0.0004465611,0.0007688874,0.0001779093,0.1191494,0.02425688,0.004510772,0.001602057,0.00004891237],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9747474,0.001177645,0.01990286,0.0002250437,0.00002185901,0.00006539714,0.002673584,0.0001208995,0.001065279],"genre_scores_gemma":[0.9914009,0.0002241125,0.006543573,0.00004674853,0.00001937136,0.0000466332,0.001312271,0.00000726027,0.0003990579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002472662,"threshold_uncertainty_score":0.0130769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0208056336985553,"score_gpt":0.3273568372490116,"score_spread":0.3065512035504563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}