{"id":"W4388214035","doi":"10.1101/2023.10.30.564869","title":"Post-fertilization transcription initiation in an ancestral LTR retrotransposon drives lineage-specific genomic imprinting of <i>ZDBF2</i>","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"NODAI Genome Research Center, Tokyo University of Agriculture; Japan Society for the Promotion of Science; Tokyo University of Agriculture; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Retrotransposon; Biology; Genomic imprinting; Genetics; DNA methylation; Epigenetics; Gene; Long terminal repeat; Exon; Genome; Transposable element; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009226897,0.0001768812,0.00009700045,0.0001451111,0.0001231125,0.0002193534,0.000206051,0.0001964258,0.001923308],"category_scores_gemma":[0.00008535814,0.0001486963,0.0001776206,0.00007031117,0.0001624426,0.00009875414,0.0002038182,0.0003901634,0.0007721713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002789305,"about_ca_system_score_gemma":0.00008463798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005706158,"about_ca_topic_score_gemma":0.001349545,"domain_scores_codex":[0.999894,0.00001357041,0.000006480137,0.00004063662,0.00002001638,0.00002532201],"domain_scores_gemma":[0.9999193,0.00001922166,0.00002636511,0.00001090072,0.000005771928,0.00001849754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002661046,0.000004104852,0.0002001035,0.000007446549,8.928171e-7,0.00002832296,0.00001272912,0.00001214869,0.9990663,0.00009172949,0.00001806672,0.0005316163],"study_design_scores_gemma":[0.00002309621,0.0001558283,0.01800665,0.00001436422,0.00001342055,0.0004605382,0.00008137173,0.001604953,0.9731717,0.00008558578,0.006374587,0.000007839137],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936585,0.0004825147,0.003578502,0.00005249231,0.00002221605,0.00001349519,0.0003313752,0.0001321329,0.001728757],"genre_scores_gemma":[0.9953336,0.0001208969,0.001285309,0.00003536376,0.000005535985,0.000007226458,0.0005105006,0.00003847443,0.002663104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001923308,"threshold_uncertainty_score":0.006434143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02316167822394065,"score_gpt":0.2361491103900183,"score_spread":0.2129874321660777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}