{"id":"W4388214872","doi":"10.1126/science.adf4154","title":"Autoregulatory control of mitochondrial glutathione homeostasis","year":2023,"lang":"en","type":"article","venue":"Science","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute","keywords":"Mitochondrion; Glutathione; Biology; Homeostasis; Cell biology; Biochemistry; Mitochondrial matrix; Oxidative phosphorylation; Enzyme; Cytosol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002561618,0.00006318292,0.00009243585,0.0000740777,0.00007681336,0.000009985126,0.0002560612,0.00004506655,0.00001111144],"category_scores_gemma":[0.0001328516,0.00005528127,0.00004971578,0.0004006612,0.0004380054,0.000004891911,0.00008697109,0.00002846484,0.00002434645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004859021,"about_ca_system_score_gemma":0.0001602419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003962403,"about_ca_topic_score_gemma":0.000001284352,"domain_scores_codex":[0.9991933,0.00001306683,0.0001125803,0.0002385307,0.0002207038,0.0002218932],"domain_scores_gemma":[0.9995258,0.000005217578,0.00004834027,0.0002659431,0.00008217919,0.00007249086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001440333,0.000008330271,0.0002336448,0.000003273803,0.000004475814,7.905516e-7,0.00003551906,0.00006437234,0.9927692,0.0004499351,0.0007768564,0.005639239],"study_design_scores_gemma":[0.0006637251,0.00009997623,0.03878396,0.000005111874,0.00001070106,0.00000412887,0.00008143674,0.0003258126,0.8782263,0.0001415422,0.08152851,0.0001287584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995856,0.0009166515,0.001807472,0.00009209492,0.0007520875,0.00009265316,0.00002447142,0.00002053246,0.0004380164],"genre_scores_gemma":[0.9985394,0.00008563888,0.0004996759,0.00008816674,0.0002036586,0.000006140763,0.000006841003,0.000006007625,0.0005644392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1145428,"threshold_uncertainty_score":0.2254305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007138263615400074,"score_gpt":0.248592753308137,"score_spread":0.2414544896927369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}