{"id":"W4388214872","doi":"10.1126/science.adf4154","title":"Autoregulatory control of mitochondrial glutathione homeostasis","year":2023,"lang":"en","type":"article","venue":"Science","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute","keywords":"Mitochondrion; Glutathione; Biology; Homeostasis; Cell biology; Biochemistry; Mitochondrial matrix; Oxidative phosphorylation; Enzyme; Cytosol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002775511,0.0002671301,0.0002588056,0.000237421,0.0001802824,0.0006093639,0.0003490124,0.0002178645,0.0006050242],"category_scores_gemma":[0.0002923336,0.00009694498,0.0001938043,0.0001231322,0.0003833652,0.0004130615,0.0005484575,0.0002851665,0.0002333999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005162624,"about_ca_system_score_gemma":0.0002811899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004261764,"about_ca_topic_score_gemma":0.0004917469,"domain_scores_codex":[0.9997926,0.00003383504,0.00001129078,0.000081844,0.00004584417,0.00003445441],"domain_scores_gemma":[0.9997935,0.00004022415,0.00004625746,0.00003371641,0.00004138805,0.00004497023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006036284,0.00000967869,0.0006518761,0.00001778666,0.000005804044,0.00008549698,0.0000504272,0.0002564871,0.9914213,0.002037598,0.0001031987,0.005299903],"study_design_scores_gemma":[0.00003659893,0.0004107978,0.02985958,0.00002181299,0.00004585397,0.0004701446,0.0002728959,0.02946966,0.9183859,0.007303908,0.01366848,0.00005451914],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9349715,0.003271786,0.05524106,0.0005376766,0.0001728732,0.00003317239,0.0002521458,0.001078003,0.004441808],"genre_scores_gemma":[0.9951925,0.0004425788,0.003049776,0.00005700859,0.00002550003,0.00001652591,0.00008900383,0.00002109869,0.001106009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006093639,"threshold_uncertainty_score":0.003745794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007138263615400074,"score_gpt":0.248592753308137,"score_spread":0.2414544896927369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}