{"id":"W4388221232","doi":"10.1016/j.stemcr.2023.10.005","title":"AT7867 promotes pancreatic progenitor differentiation of human iPSCs","year":2023,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Breakthrough T1D Canada; Alberta Diabetes Foundation; Juvenile Diabetes Research Foundation Canada; Canada Research Chairs; Stem Cell Network; Diabetes Canada; Diabetes Research Institute Foundation","keywords":"PDX1; Biology; Progenitor cell; Downregulation and upregulation; Transplantation; Internal medicine; Stem cell; Andrology; In vivo; Endocrinology; Cellular differentiation; Diabetes mellitus; Cell biology; Islet; Medicine; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002147804,0.0001214731,0.0003359077,0.0001375186,0.00005954498,0.0000103315,0.00002544708,0.00007186135,0.0001290368],"category_scores_gemma":[0.00005490681,0.00009797546,0.0001085858,0.0002935813,0.00003400582,0.00003991325,0.00002485382,0.00006480758,0.00006495387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003080718,"about_ca_system_score_gemma":0.00008288713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000116717,"about_ca_topic_score_gemma":8.039436e-7,"domain_scores_codex":[0.9987416,0.00003043423,0.0004772568,0.0002339593,0.0003248799,0.000191856],"domain_scores_gemma":[0.9990876,0.00005134548,0.0002836811,0.0003631023,0.0001100674,0.0001041792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002183564,0.000192062,0.451304,0.0008814354,0.00008484557,0.0002200541,0.0003700307,0.00000106194,0.544035,0.00004753687,0.001740577,0.001101568],"study_design_scores_gemma":[0.0007184384,0.0004710036,0.2509142,0.0002724177,0.0003617872,0.00008690066,0.0004430049,0.0001767843,0.7451917,0.0003600525,0.0008327721,0.0001708987],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864266,0.0001353343,0.00001122053,0.00004932178,0.0002773957,0.000526128,0.000002228058,0.000206912,0.01236486],"genre_scores_gemma":[0.9845881,0.00001005514,0.00007487959,0.00001638647,0.0001062158,0.00005397802,0.0001303336,0.00002245278,0.01499758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2011567,"threshold_uncertainty_score":0.3995323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02254580857147085,"score_gpt":0.2601928228057876,"score_spread":0.2376470142343168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}