{"id":"W4388221232","doi":"10.1016/j.stemcr.2023.10.005","title":"AT7867 promotes pancreatic progenitor differentiation of human iPSCs","year":2023,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Breakthrough T1D Canada; Alberta Diabetes Foundation; Juvenile Diabetes Research Foundation Canada; Canada Research Chairs; Stem Cell Network; Diabetes Canada; Diabetes Research Institute Foundation","keywords":"PDX1; Biology; Progenitor cell; Downregulation and upregulation; Transplantation; Internal medicine; Stem cell; Andrology; In vivo; Endocrinology; Cellular differentiation; Diabetes mellitus; Cell biology; Islet; Medicine; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001704089,0.0004300732,0.000465237,0.0003921528,0.0001513688,0.0005094985,0.0002213875,0.0002874904,0.002326397],"category_scores_gemma":[0.0001254737,0.0001566749,0.0004152445,0.0002685753,0.0001489039,0.0001714903,0.0003247747,0.0009771362,0.0009276302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001386217,"about_ca_system_score_gemma":0.0002797705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006111201,"about_ca_topic_score_gemma":0.0008107295,"domain_scores_codex":[0.9997956,0.00001977954,0.00002278644,0.00003286186,0.00008797654,0.00004109481],"domain_scores_gemma":[0.9999199,0.00001221524,0.00001553868,0.00000858966,0.00001467141,0.0000291117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007568423,0.0002442477,0.0004955551,0.0003484342,0.00003573551,0.0002575311,0.00008815285,0.0005435295,0.9761543,0.0003031759,0.0008013785,0.01997119],"study_design_scores_gemma":[0.0001170607,0.001288838,0.005136278,0.00006485858,0.000125626,0.0007613083,0.00009589628,0.001433287,0.975967,0.0001610907,0.01483327,0.00001552881],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824591,0.00445724,0.003778463,0.0001727897,0.0001390925,0.0001003222,0.0009494909,0.0002020947,0.007741353],"genre_scores_gemma":[0.9877772,0.003518197,0.002438144,0.0001719078,0.00004278525,0.00009592489,0.001414884,0.00007258753,0.004468494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002326397,"threshold_uncertainty_score":0.007782578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02254580857147085,"score_gpt":0.2601928228057876,"score_spread":0.2376470142343168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}