{"id":"W4388233306","doi":"10.1186/s12964-023-01337-4","title":"p38 MAPK signaling in chronic obstructive pulmonary disease pathogenesis and inhibitor therapeutics","year":2023,"lang":"en","type":"review","venue":"Cell Communication and Signaling","topic":"Chronic Obstructive Pulmonary Disease (COPD) Research","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"","keywords":"COPD; Medicine; Pathogenesis; Immune system; Disease; Immunology; p38 mitogen-activated protein kinases; Bioinformatics; MAPK/ERK pathway; Signal transduction; Pathology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008223072,0.001031749,0.00442804,0.01200358,0.0006371803,0.002362989,0.001402343,0.001726887,0.008071722],"category_scores_gemma":[0.01511091,0.000454951,0.004034897,0.008390437,0.0008630789,0.002454859,0.001295411,0.001102332,0.001194364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001760825,"about_ca_system_score_gemma":0.00861725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001156267,"about_ca_topic_score_gemma":0.00284771,"domain_scores_codex":[0.9955448,0.001311734,0.001851922,0.0002708939,0.0008719104,0.0001486542],"domain_scores_gemma":[0.9883507,0.007186437,0.00273529,0.0001582366,0.001343379,0.0002258666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006988339,0.00005487277,0.001050718,0.814566,0.001871238,0.0002279959,0.0001859186,0.0001407433,0.00100522,0.001340815,0.007263269,0.1715945],"study_design_scores_gemma":[0.0008658912,0.0007828466,0.008841857,0.6920154,0.02109564,0.00139456,0.0005383916,0.0003570807,0.001623267,0.005192167,0.2671924,0.000100478],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00122131,0.9943652,0.0003333844,0.001433144,0.000290783,0.0004193732,0.0008160424,0.00001737843,0.001103315],"genre_scores_gemma":[0.01315253,0.980873,0.001990457,0.001116623,0.0004564626,0.001109265,0.0007740755,0.00001202322,0.000515459],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01200358,"threshold_uncertainty_score":0.04348826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07334331042502261,"score_gpt":0.3454439153188497,"score_spread":0.2721006048938271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}