{"id":"W4388263325","doi":"10.3390/v15112152","title":"A Method to Generate and Rescue Recombinant Adenovirus Devoid of Replication-Competent Particles in Animal-Origin-Free Culture Medium","year":2023,"lang":"en","type":"article","venue":"Viruses","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; National Research Council Canada","funders":"National Research Council Canada","keywords":"Cell culture; Fetal bovine serum; Limiting; Recombinant DNA; Biology; HEK 293 cells; Adenoviridae; Virology; Genetic enhancement; Molecular biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008685816,0.001223542,0.0006501144,0.0013549,0.0006511652,0.0005193373,0.0008216735,0.000995285,0.00118602],"category_scores_gemma":[0.0004603533,0.0005820213,0.0008748156,0.0005612351,0.0004806236,0.0005130838,0.0005741442,0.001767483,0.002137667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003429222,"about_ca_system_score_gemma":0.0005896703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005369625,"about_ca_topic_score_gemma":0.0006782312,"domain_scores_codex":[0.9991997,0.0001227825,0.0001416389,0.0001911252,0.0002901107,0.00005466062],"domain_scores_gemma":[0.9996988,0.00006942973,0.00005140514,0.00009403003,0.00004908894,0.00003740185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002287067,0.00006162785,0.00007334685,0.0001421599,0.000008368188,0.0000972207,0.0000321271,0.0000566526,0.9923868,0.0004396623,0.0002265032,0.006452661],"study_design_scores_gemma":[0.00001995174,0.0002387283,0.0005739857,0.00002226903,0.00003885228,0.001418401,0.00001280816,0.0007486148,0.9730554,0.0001715591,0.02367171,0.00002774201],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.101134,0.007675536,0.8780212,0.0005330833,0.0007200407,0.002008568,0.001709488,0.00262729,0.005570771],"genre_scores_gemma":[0.2400867,0.01033128,0.723489,0.000342855,0.0001468902,0.002477564,0.00567445,0.000463985,0.01698735],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.0013549,"threshold_uncertainty_score":0.004593611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04998392221154269,"score_gpt":0.3692879281958008,"score_spread":0.3193040059842581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}