{"id":"W4388266870","doi":"10.3390/cancers15215136","title":"Auranofin Induces Lethality Driven by Reactive Oxygen Species in High-Grade Serous Ovarian Cancer Cells","year":2023,"lang":"en","type":"article","venue":"Cancers","topic":"Redox biology and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Health Canada; Ovarian Cancer Canada","keywords":"Auranofin; Reactive oxygen species; Thioredoxin reductase; Cancer research; Programmed cell death; Chemistry; Apoptosis; Cancer cell; Buthionine sulfoximine; Ovarian cancer; Thioredoxin; Glutathione; Carboplatin; DNA damage; Pharmacology; Cisplatin; Cancer; Medicine; Oxidative stress; Chemotherapy; Biochemistry; Immunology; Internal medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009302574,0.0002106282,0.0002716102,0.0001455491,0.000130323,0.0001687565,0.0000847332,0.0001871013,0.0006651129],"category_scores_gemma":[0.00008204261,0.00007515018,0.0002031548,0.0001846319,0.0001160248,0.0001027646,0.0001557685,0.0003079658,0.0001232155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001719667,"about_ca_system_score_gemma":0.0001570764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001193379,"about_ca_topic_score_gemma":0.001350296,"domain_scores_codex":[0.999892,0.00001808139,0.00001169254,0.00001779241,0.00003158541,0.00002882436],"domain_scores_gemma":[0.9999465,0.00001051139,0.00001309268,0.00001052891,0.00000807197,0.00001123517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002748711,0.0000824206,0.001242659,0.00007586123,0.00001422921,0.0002455505,0.00006753708,0.0001229375,0.9941416,0.00009476091,0.0001577605,0.003479801],"study_design_scores_gemma":[0.00007089548,0.001491073,0.01798227,0.000007888936,0.00003008481,0.0008205872,0.0000984565,0.001363937,0.9747062,0.0000572408,0.003364356,0.000006971202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974765,0.0007604694,0.0005996976,0.00005285778,0.00001842743,0.00002335722,0.0001621768,0.00003488475,0.0008715452],"genre_scores_gemma":[0.9987013,0.0002460564,0.0002519119,0.00003454929,0.000003511203,0.0000179624,0.0001857425,0.000002664478,0.0005562994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001193379,"threshold_uncertainty_score":0.002372921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01877997688313086,"score_gpt":0.2764126179356232,"score_spread":0.2576326410524923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}