{"id":"W4388267603","doi":"10.1016/j.jcjd.2023.10.330","title":"LOSS OF THIOREDOXIN-INTERACTING PROTEIN (TXNIP) MEDIATES SENESCENCE IN RENAL MESANGIAL CELLS ASSOCIATED WITH HYPERACTIVATION OF AKT AND RAS; A POTENTIAL ADVERSE EFFECT OF THERAPEUTIC TARGETING","year":2023,"lang":"en","type":"article","venue":"Canadian Journal of Diabetes","topic":"Vitamin C and Antioxidants Research","field":"Nursing","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"TXNIP; Thioredoxin-Interacting Protein; Downregulation and upregulation; Thioredoxin; Medicine; Cancer research; Protein kinase B; Oxidative stress; PI3K/AKT/mTOR pathway; Endocrinology; Warburg effect; Context (archaeology); Internal medicine; Cancer cell; Cell biology; Biology; Signal transduction; Cancer; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000397246,0.0002658817,0.0003171736,0.0003656043,0.0003751477,0.0003986559,0.0003033905,0.000441369,0.001259986],"category_scores_gemma":[0.0001970991,0.0002487086,0.0004749964,0.0002756507,0.0003751586,0.0003844472,0.0002469445,0.0009720423,0.0002659984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003386994,"about_ca_system_score_gemma":0.0004554518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001147563,"about_ca_topic_score_gemma":0.001544622,"domain_scores_codex":[0.999768,0.00004305959,0.00002460254,0.00003333928,0.00005987596,0.00007125433],"domain_scores_gemma":[0.9998554,0.00001926179,0.00004406394,0.0000245351,0.00001683336,0.00003982683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005676918,0.000123335,0.0005692081,0.00004941613,0.00001863115,0.0002961291,0.00004412048,0.00006301413,0.9963371,0.0003365588,0.00008656993,0.00150824],"study_design_scores_gemma":[0.00007586183,0.0008414671,0.01371102,0.00001030247,0.00005913063,0.00104308,0.0001637806,0.001398302,0.9802751,0.0001831447,0.002229522,0.000009372801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963076,0.001148665,0.001212408,0.0001596407,0.00003993198,0.00001703969,0.00009562371,0.00006085968,0.0009583246],"genre_scores_gemma":[0.9979743,0.0004533117,0.0004757975,0.00003437564,0.000006141832,0.00001496876,0.00009503312,0.000007082134,0.0009389049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001259986,"threshold_uncertainty_score":0.004215062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007404004460325269,"score_gpt":0.2385808862712654,"score_spread":0.2311768818109401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}