{"id":"W4388283999","doi":"10.1038/s42003-023-05454-1","title":"Identification of circulating proteins associated with general cognitive function among middle-aged and older adults","year":2023,"lang":"en","type":"article","venue":"Communications Biology","topic":"Machine Learning in Bioinformatics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill Genome Centre","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Deafness and Other Communication Disorders; National Human Genome Research Institute; National Institute on Drug Abuse; National Heart, Lung, and Blood Institute; National Institute on Aging; Biotechnology and Biological Sciences Research Council; National Center for Advancing Translational Sciences; Medical Research Council; Hjartavernd; Age UK; Université de Bordeaux; Fondation de France; Bundesministerium für Bildung und Forschung; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Deutsches Zentrum für Neurodegenerative Erkrankungen; Deutsche Forschungsgemeinschaft; U.S. Department of Health and Human Services; Economic and Social Research Council; National Institute of Diabetes and Digestive and Kidney Diseases; Sanofi; European Commission; National Center for Research Resources; Agence Nationale de la Recherche; Scottish Government; Mutuelle Générale de l'Education Nationale; Royal Society; Directorate for Biological Sciences; National Institutes of Health","keywords":"Mendelian randomization; Cognition; Biology; Disease; Dementia; Alzheimer's disease; Function (biology); Neuroscience; Genetics; Bioinformatics; Medicine; Internal medicine; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003465618,0.00009435298,0.0001141526,0.00008258625,0.0001782835,0.00001150529,0.0002095096,0.0001464391,0.000003647367],"category_scores_gemma":[0.0005147654,0.00008705523,0.00002724758,0.0002341203,0.0003262369,0.000007042523,0.00022042,0.0001319898,0.00000367734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007376659,"about_ca_system_score_gemma":0.00002629305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002188929,"about_ca_topic_score_gemma":0.0001399987,"domain_scores_codex":[0.9991536,0.0002197089,0.0002875256,0.0001582949,0.00004971896,0.0001311225],"domain_scores_gemma":[0.9988878,0.00008204876,0.0003128464,0.0005229928,0.0001665921,0.00002773433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000131049,0.0001688385,0.6944276,0.0001072357,0.0003934372,3.662633e-7,0.001816974,0.0001641755,0.2927203,0.00111598,0.000093145,0.008860867],"study_design_scores_gemma":[0.001074126,0.0003233489,0.970314,0.0001332211,0.00007220959,0.000004961905,0.0008155205,0.02243745,0.004449794,0.00009136413,0.00008558592,0.0001984801],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951672,0.000159638,0.00380142,0.00006944452,0.00002578976,0.0003757733,0.00003819759,0.00004063308,0.0003219316],"genre_scores_gemma":[0.996298,0.00009410412,0.0005121095,0.00003454524,0.00001739977,0.00009954724,0.002778238,0.0000134035,0.0001527217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2882705,"threshold_uncertainty_score":0.3550009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0174086657713284,"score_gpt":0.2693452914268503,"score_spread":0.2519366256555219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}