{"id":"W4388290576","doi":"10.1016/j.labinv.2023.100281","title":"A Multicenter Study Validates the WHO 2022 Classification for Conjunctival Melanocytic Intraepithelial Lesions With Clinical and Prognostic Relevance","year":2023,"lang":"en","type":"review","venue":"Laboratory Investigation","topic":"Ocular Oncology and Treatments","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Queen's University; University of Ottawa","funders":"National Eye Institute; Liverpool University Hospitals NHS Foundation Trust; National Institute for Health and Care Research","keywords":"Medicine; Grading (engineering); Melanoma; H&E stain; Pathology; Breslow Thickness; Conjunctiva; Scoring system; Pagetoid; Melanosis; Intraepithelial neoplasia; Ophthalmic pathology; Dermatology; Immunohistochemistry; Internal medicine; Ophthalmology; Cancer; Neuro-ophthalmology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005924224,0.0005858199,0.0005507778,0.001385426,0.0008852266,0.001032484,0.0006247938,0.0007333708,0.00185878],"category_scores_gemma":[0.0115363,0.0003103107,0.0006257011,0.001469432,0.0005050699,0.0008376027,0.0008964262,0.0003911938,0.000775265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004658468,"about_ca_system_score_gemma":0.0006132515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002721396,"about_ca_topic_score_gemma":0.002928854,"domain_scores_codex":[0.9957282,0.001418905,0.0005533667,0.001191168,0.0007550307,0.0003532267],"domain_scores_gemma":[0.9900114,0.002069031,0.00288005,0.002128103,0.002268337,0.0006431813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000148512,0.00002947035,0.9965075,0.00001452364,0.00006016409,0.0001057213,0.0001225438,0.00002145284,0.0005520675,0.00003603875,0.0002113869,0.002190613],"study_design_scores_gemma":[0.000038487,0.0002080219,0.9955988,0.00001929612,0.0001097892,0.001109496,0.0002596534,0.0003328091,0.0003093454,0.0000582172,0.001947443,0.000008559606],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9952174,0.0006185597,0.001136988,0.00006960284,0.0000378072,0.0001187144,0.0008105644,0.00002102578,0.001969242],"genre_scores_gemma":[0.9975057,0.00006913315,0.000731757,0.0000601139,0.00003518689,0.00006790846,0.001299306,0.00001734149,0.0002136019],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.005924224,"threshold_uncertainty_score":0.03133065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1410648761584364,"score_gpt":0.4144339272088169,"score_spread":0.2733690510503805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}