{"id":"W4388290576","doi":"10.1016/j.labinv.2023.100281","title":"A Multicenter Study Validates the WHO 2022 Classification for Conjunctival Melanocytic Intraepithelial Lesions With Clinical and Prognostic Relevance","year":2023,"lang":"en","type":"review","venue":"Laboratory Investigation","topic":"Ocular Oncology and Treatments","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Queen's University; University of Ottawa","funders":"National Eye Institute; Liverpool University Hospitals NHS Foundation Trust; National Institute for Health and Care Research","keywords":"Medicine; Grading (engineering); Melanoma; H&E stain; Pathology; Breslow Thickness; Conjunctiva; Scoring system; Pagetoid; Melanosis; Intraepithelial neoplasia; Ophthalmic pathology; Dermatology; Immunohistochemistry; Internal medicine; Ophthalmology; Cancer; Neuro-ophthalmology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008348867,0.0003092591,0.0009566914,0.00009549108,0.0002455541,0.00003886422,0.00009925962,0.0002856,0.000003738963],"category_scores_gemma":[0.001634003,0.0001735708,0.0001028779,0.0004449202,0.0004764913,0.00008718294,0.00003629826,0.0004673917,0.00004296462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009185702,"about_ca_system_score_gemma":0.0008610379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004299572,"about_ca_topic_score_gemma":0.00003741842,"domain_scores_codex":[0.9976609,0.0007387879,0.0006443534,0.0005451337,0.0002204194,0.0001904182],"domain_scores_gemma":[0.9971208,0.001623443,0.0004378233,0.0004137304,0.0002672043,0.0001369887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001219715,0.002683726,0.4523302,0.0258297,0.008371491,0.0002868351,0.002330254,0.000002147004,0.000019977,0.00219891,0.002646215,0.5020809],"study_design_scores_gemma":[0.01807103,0.01002696,0.2066347,0.0306841,0.04807494,0.00006567925,0.002024063,0.0008690205,0.0000401133,0.0008042142,0.6813986,0.001306645],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1591557,0.8167989,0.0001005143,0.001049695,0.0008680339,0.02128397,0.0004424739,0.0002797146,0.00002091753],"genre_scores_gemma":[0.00856001,0.9842048,0.000848158,0.0003608622,0.0005757998,0.004110175,0.0008247736,0.0001427282,0.0003726631],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6787524,"threshold_uncertainty_score":0.7078013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1410648761584364,"score_gpt":0.4144339272088169,"score_spread":0.2733690510503805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}