{"id":"W4388300801","doi":"10.1101/2023.11.01.564830","title":"Recruitment of FBXO22 for Targeted Degradation of NSD2","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Princess Margaret Cancer Centre; York University; University of Toronto; University Health Network","funders":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill; Division of Chemistry; Natural Sciences and Engineering Research Council of Canada; Genentech; Ontario Genomics Institute; National Cancer Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; McGill University; Florida Department of Health; National Institutes of Health; Ontario Genomics; Genome Canada; Leukemia and Lymphoma Society; Bayer; Princess Margaret Cancer Foundation; Pfizer; Canadian Institutes of Health Research; National Science Foundation","keywords":"Degradation (telecommunications); Computer science; Telecommunications","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001756724,0.0002546398,0.0001390032,0.00008540146,0.0001279633,0.0001875162,0.0001091432,0.0002058765,0.001315704],"category_scores_gemma":[0.00008616713,0.00009413836,0.0001342977,0.0000662638,0.0001652026,0.0001038156,0.0002255617,0.0002427044,0.0004540804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002956193,"about_ca_system_score_gemma":0.0001847308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003920091,"about_ca_topic_score_gemma":0.0006523184,"domain_scores_codex":[0.9998984,0.00002092972,0.000009840972,0.0000201217,0.00003094602,0.00001956458],"domain_scores_gemma":[0.9999593,0.000004862517,0.00001193723,0.00000733461,0.000004854808,0.0000116338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005503655,0.000008591546,0.000120728,0.00001404725,0.000001926856,0.00004626218,0.000007551719,0.00006371061,0.9988641,0.00009126525,0.00004735745,0.0006794969],"study_design_scores_gemma":[0.0000055964,0.00004440662,0.0004548396,8.29348e-7,0.000001145412,0.00007785211,0.000003491116,0.0003235046,0.9978362,0.00001093057,0.001240079,0.000001180744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987214,0.0007561258,0.008918794,0.000124391,0.00002869325,0.00006028976,0.0002505613,0.000132523,0.002514697],"genre_scores_gemma":[0.9886876,0.0003345826,0.006135602,0.00005373375,0.000006569551,0.00003195803,0.0002326938,0.00002306841,0.004494102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001315704,"threshold_uncertainty_score":0.004401505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05083311290786306,"score_gpt":0.2690810564730959,"score_spread":0.2182479435652329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}