{"id":"W4388300944","doi":"10.1101/2023.10.31.564979","title":"Structural determinants of pure antiestrogenicity","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; University of British Columbia; Institute for Research in Immunology and Cancer","funders":"Biological and Environmental Research; Office of Science; Argonne National Laboratory; Susan G. Komen for the Cure; U.S. Department of Energy","keywords":"Coactivator; SUMO protein; Fulvestrant; Chemistry; Estrogen receptor; Estrogen receptor alpha; Cell biology; Cancer research; Biophysics; Transcription factor; Biochemistry; Biology; Genetics; Cancer; Ubiquitin; Breast cancer; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006366944,0.0001948613,0.0001434087,0.00007333032,0.0001188926,0.0002116485,0.0001825131,0.0001495488,0.001329204],"category_scores_gemma":[0.0001049487,0.0001047078,0.0001297978,0.00008523329,0.0001492617,0.0001102378,0.0001199254,0.000247252,0.0003413025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002100392,"about_ca_system_score_gemma":0.0001064368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005288399,"about_ca_topic_score_gemma":0.000723073,"domain_scores_codex":[0.9999577,0.000005605111,0.000002297811,0.000008746343,0.00001501382,0.00001068988],"domain_scores_gemma":[0.999951,0.000009727463,0.00001266896,0.000005239237,0.00000837369,0.00001299815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002600593,0.00003270602,0.001194279,0.00004105525,0.0000151092,0.0001105268,0.00001487081,0.001396151,0.9946622,0.00044953,0.000147316,0.001676321],"study_design_scores_gemma":[0.00004684459,0.0002417511,0.00759758,0.000007206564,0.0000232757,0.000301072,0.00003952969,0.01151588,0.9769867,0.000308556,0.002922228,0.000009307993],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969257,0.000363733,0.001342819,0.00004515877,0.000006918193,0.000006004952,0.0001890097,0.0000381756,0.001082486],"genre_scores_gemma":[0.9987882,0.0001326749,0.0004155184,0.00001817766,0.000001910563,0.000003440996,0.000223061,0.000009237855,0.0004079079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001329204,"threshold_uncertainty_score":0.004446685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02235604677099092,"score_gpt":0.2446369843816397,"score_spread":0.2222809376106487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}