{"id":"W4388302569","doi":"10.2174/0113816128244442231018070639","title":"Impact of Breaking up of Sitting Time on Anti-inflammatory Response Induced by Extracellular Vesicles","year":2023,"lang":"en","type":"review","venue":"Current Pharmaceutical Design","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Macrophage polarization; Inflammation; Immune system; Extracellular vesicles; Paracrine signalling; Sitting; Cell biology; Secretion; Macrophage; Phenotype; Homeostasis; Extracellular; Medicine; Immunology; Biology; Internal medicine; In vitro; Pathology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001882908,0.0007105415,0.001390173,0.0002438254,0.00006873785,0.00002809968,0.0007567517,0.0005167515,0.00006634765],"category_scores_gemma":[0.0009352486,0.0006376046,0.001189968,0.0003795288,0.0002403296,0.000009106253,0.0002931311,0.0006206269,0.000134295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001035385,"about_ca_system_score_gemma":0.0007471616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":7.812813e-7,"about_ca_topic_score_gemma":9.354268e-9,"domain_scores_codex":[0.9948869,0.001863481,0.001324418,0.0008417076,0.0004782071,0.0006053202],"domain_scores_gemma":[0.9970759,0.0006925889,0.0008856044,0.0008471312,0.0001349153,0.000363858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006296686,0.0003773333,0.00001463375,0.005893278,0.0005183414,0.00002118159,0.00001864445,0.00002180921,0.6524031,0.000009564809,0.001854741,0.3382377],"study_design_scores_gemma":[0.003219551,0.002256782,0.0001234784,0.026946,0.003372934,0.00005008023,0.00001943474,0.0009446234,0.5890107,0.00005311186,0.3711255,0.002877777],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0785399,0.9189573,0.0006728519,0.000003132123,0.0003172017,0.001122115,0.0003249698,0.00004914446,0.0000133817],"genre_scores_gemma":[0.03484133,0.9638548,0.00009726541,0.000005536871,0.0002761497,0.00007374855,0.0004551017,0.0002446828,0.000151405],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.3692708,"threshold_uncertainty_score":0.9996075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1345988638757678,"score_gpt":0.4334603094481149,"score_spread":0.2988614455723471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}