{"id":"W4388304849","doi":"10.3390/vaccines11111682","title":"Immunogenicity and Efficacy of TNX-1800, A Live Virus Recombinant Poxvirus Vaccine Candidate, against SARS-CoV-2 Challenge in Nonhuman Primates","year":2023,"lang":"en","type":"article","venue":"Vaccines","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; University of Alberta","keywords":"Immunogenicity; Virology; Biology; Vaccination; Neutralizing antibody; Virus; Titer; Antibody; Recombinant DNA; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006243677,0.0003703499,0.0008799655,0.0008013752,0.0001157217,0.00003529479,0.0003012087,0.0002013232,0.00001517428],"category_scores_gemma":[0.0004238947,0.0003078987,0.0001514077,0.001064034,0.00004879179,0.0001498971,0.0003445517,0.0003935968,0.0001508562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001252934,"about_ca_system_score_gemma":0.0001969192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004308872,"about_ca_topic_score_gemma":0.002826745,"domain_scores_codex":[0.9974906,0.0001058312,0.0007148899,0.0006183441,0.0003770483,0.0006932717],"domain_scores_gemma":[0.9985793,0.0003382715,0.000172694,0.0006543362,0.0002008496,0.00005449917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002845339,0.001008003,0.1006584,0.0007948385,0.0002467725,0.0004701197,0.002381895,9.029326e-7,0.876547,0.00007632821,0.001285015,0.01368541],"study_design_scores_gemma":[0.0142149,0.00126956,0.3787212,0.000636921,0.0001125886,0.00005661608,0.0005007414,0.0007911351,0.5921676,0.0003323519,0.01066114,0.0005352894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939643,0.003410851,0.00000121104,0.0005964747,0.0001948011,0.0009101309,0.00002758978,0.0001747657,0.0007198557],"genre_scores_gemma":[0.9959577,0.00163863,0.00003655026,0.002022325,0.0001225852,0.00007795831,0.00002859884,0.00007001151,0.00004569386],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2843794,"threshold_uncertainty_score":0.9999373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04466155740299509,"score_gpt":0.3446895454879856,"score_spread":0.3000279880849905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}