{"id":"W4388307559","doi":"10.1039/d3ob01539d","title":"Chimeric GFP–uracil based molecular rotor fluorophores","year":2023,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Fluorescence; Uracil; Solvatochromism; Green fluorescent protein; Chromophore; Photochemistry; DNA; Solvent polarity; Residue (chemistry); Nucleic acid; Combinatorial chemistry; Solvent; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001146887,0.0002744968,0.0002465028,0.0001170046,0.0001143384,0.0002517697,0.0003022455,0.0002719497,0.001409701],"category_scores_gemma":[0.000095667,0.0001044589,0.0001648874,0.000158894,0.000148245,0.0001551734,0.0001996318,0.0004518648,0.0006065923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002989347,"about_ca_system_score_gemma":0.0001436478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003617166,"about_ca_topic_score_gemma":0.0005282978,"domain_scores_codex":[0.9999195,0.000009874695,0.000004852397,0.0000243553,0.00002096772,0.0000203435],"domain_scores_gemma":[0.9999372,0.00001087275,0.00001442655,0.000009009978,0.00001069157,0.00001774008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002554743,0.000007863501,0.000043227,0.00001399219,0.000001509368,0.0000254657,0.000007315302,0.0000955293,0.9985803,0.000198865,0.00001895568,0.0009812744],"study_design_scores_gemma":[0.000004298707,0.00009405171,0.0004562246,0.000002173144,0.000005900371,0.0001462534,0.000008086662,0.0007384653,0.9948081,0.00002795826,0.003704557,0.000003908255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9766387,0.0006917935,0.01961705,0.00008133533,0.00003510662,0.00004986693,0.0005200827,0.000302255,0.00206373],"genre_scores_gemma":[0.9771687,0.0005257556,0.01658092,0.00003071892,0.000005196564,0.00004828144,0.0008369492,0.00006045642,0.004742913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001409701,"threshold_uncertainty_score":0.004715919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004290587277917732,"score_gpt":0.2157120189466847,"score_spread":0.211421431668767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}