{"id":"W4388363914","doi":"10.1016/j.ibneur.2023.08.957","title":"DISTINCT EFFECTS OF THE Β2-ADRENERGIC AGONIST FORMOTEROL AND THE CHOLINESTERASE INHIBITOR PYRIDOSTIGMINE IN A NEW MURINE MYASTHENIA MODEL WITH SPECIFIC VACHT DELETION IN MOTOR NEURONS","year":2023,"lang":"en","type":"article","venue":"IBRO Neuroscience Reports","topic":"Chemical Reactions and Isotopes","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials","funders":"","keywords":"Pyridostigmine; Pyridostigmine Bromide; Cholinesterase; Agonist; Formoterol; Adrenergic; Endocrinology; Pharmacology; Internal medicine; Medicine; Myasthenia gravis; Chemistry; Receptor; Corticosteroid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002325014,0.0008362644,0.0006519597,0.0006450585,0.0001913163,0.0003138522,0.0004555477,0.0007079003,0.001171341],"category_scores_gemma":[0.0001235466,0.0002328335,0.0004920078,0.0001802461,0.0005539057,0.0005033471,0.0002267319,0.001207355,0.0002609429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003562575,"about_ca_system_score_gemma":0.0003101258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007691431,"about_ca_topic_score_gemma":0.001219404,"domain_scores_codex":[0.9996691,0.00004643712,0.00003575596,0.00009016781,0.00006753391,0.00009101611],"domain_scores_gemma":[0.9997839,0.00002053326,0.00006628554,0.00001947337,0.00001429139,0.00009547394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001068225,0.0004878729,0.0001500618,0.0000617519,0.00001359873,0.0001564399,0.00002774487,0.00007705358,0.9963635,0.00009932145,0.00006685057,0.00142764],"study_design_scores_gemma":[0.0005204538,0.01276221,0.004334318,0.00002733578,0.0001292641,0.0007953486,0.00008306487,0.001081113,0.977986,0.0001058204,0.002151038,0.00002403121],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995878,0.001403354,0.001017007,0.0001474838,0.00008293333,0.00008711951,0.000402839,0.00008964597,0.0008915667],"genre_scores_gemma":[0.9919937,0.001405704,0.001951675,0.0001086549,0.00003864995,0.0002076855,0.0005407102,0.00002597363,0.003727289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001171341,"threshold_uncertainty_score":0.003918529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04257802947191257,"score_gpt":0.3369581460532002,"score_spread":0.2943801165812876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}