{"id":"W4388363942","doi":"10.1016/j.ibneur.2023.08.885","title":"LONG-TERM Β2 ADRENERGIC AGONIST TREATMENT INCREASES LIFE SPAN AND AMELIORATE MOTOR IMPAIRMENT IN A MYASTHENIA MODEL WITH SPECIFIC VACHT DELETION IN MOTOR NEURONS (MN-VACHT-KD)","year":2023,"lang":"en","type":"article","venue":"IBRO Neuroscience Reports","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials","funders":"","keywords":"Agonist; Life span; Adrenergic; Medicine; Term (time); Neuroscience; Internal medicine; Endocrinology; Biology; Receptor; Physics; Gerontology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000104786,0.0004343454,0.0003511953,0.0003027571,0.0001325274,0.0001515028,0.0002559049,0.0004161447,0.001788209],"category_scores_gemma":[0.000069783,0.000115207,0.0002334041,0.00009906106,0.0001981154,0.0002573382,0.0001516022,0.0008879801,0.0003600248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001228932,"about_ca_system_score_gemma":0.0001506309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003836281,"about_ca_topic_score_gemma":0.0007560916,"domain_scores_codex":[0.9999061,0.00001101731,0.00001096597,0.00002124501,0.00001773155,0.00003298604],"domain_scores_gemma":[0.99983,0.000009850017,0.00004089616,0.0000112766,0.00001143183,0.00009647978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008148667,0.0003971549,0.0002483609,0.00005738593,0.00001283707,0.00008229904,0.00002118219,0.00004974315,0.9956896,0.00004384007,0.0001906417,0.002392122],"study_design_scores_gemma":[0.0005582638,0.02259712,0.03077736,0.00006977968,0.0001323047,0.001166404,0.000189405,0.001407598,0.9372009,0.0001876855,0.005684643,0.00002853684],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955481,0.002151664,0.0006778259,0.0001693064,0.00008590364,0.00002463306,0.0003774368,0.0001490245,0.0008159954],"genre_scores_gemma":[0.991522,0.001293685,0.0008968209,0.0001634982,0.00003430564,0.0000884482,0.0007531451,0.00002601441,0.005222116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001788209,"threshold_uncertainty_score":0.005982101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02164242921576248,"score_gpt":0.2536240563949104,"score_spread":0.2319816271791479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}