{"id":"W4388364090","doi":"10.1016/j.ibneur.2023.08.891","title":"A GENOME-WIDE CRISPR/CAS9 SCREENING IDENTIFIES GENETIC MODIFIERS OF ΑLPHA SYNUCLEIN AGGREGATES UPTAKE","year":2023,"lang":"en","type":"article","venue":"IBRO Neuroscience Reports","topic":"Plant tissue culture and regeneration","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Drug Policy Research Network; Montreal Neurological Institute and Hospital; Université du Québec à Montréal","funders":"","keywords":"CRISPR; Biology; Genetics; Computational biology; Genome; Cas9; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002975712,0.0003992293,0.0003400902,0.0003318574,0.0002523585,0.0004476458,0.0003431927,0.000594302,0.001085765],"category_scores_gemma":[0.0002747301,0.0001925579,0.0003266117,0.0001771193,0.0003507861,0.0001542382,0.0003472369,0.0005916897,0.0003916748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003524196,"about_ca_system_score_gemma":0.0002999856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001186668,"about_ca_topic_score_gemma":0.002427271,"domain_scores_codex":[0.9997023,0.00002360272,0.000032205,0.0001009871,0.00009292681,0.00004800558],"domain_scores_gemma":[0.9997866,0.00006639669,0.00005768803,0.00003350596,0.00002517751,0.00003068716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002112772,0.00001130674,0.00009306781,0.00001398397,0.000002955357,0.00005265161,0.00001100147,0.00004239516,0.9990721,0.00005585307,0.00001945447,0.0006041242],"study_design_scores_gemma":[0.000006674997,0.0001123108,0.00315716,0.000005048224,0.0000214208,0.0002537378,0.0000319635,0.001272968,0.993432,0.00004933289,0.001648905,0.000008482581],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9723443,0.0007150671,0.0209206,0.0001794996,0.00004955952,0.0001775431,0.001664331,0.0005608153,0.003388102],"genre_scores_gemma":[0.9792699,0.0005968623,0.01398836,0.0001123074,0.000004957269,0.00009255293,0.001144337,0.00009175117,0.004698964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001186668,"threshold_uncertainty_score":0.003632247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02250562585009144,"score_gpt":0.2613986707754525,"score_spread":0.2388930449253611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}