{"id":"W4388364090","doi":"10.1016/j.ibneur.2023.08.891","title":"A GENOME-WIDE CRISPR/CAS9 SCREENING IDENTIFIES GENETIC MODIFIERS OF ΑLPHA SYNUCLEIN AGGREGATES UPTAKE","year":2023,"lang":"en","type":"article","venue":"IBRO Neuroscience Reports","topic":"Plant tissue culture and regeneration","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Drug Policy Research Network; Montreal Neurological Institute and Hospital; Université du Québec à Montréal","funders":"","keywords":"CRISPR; Biology; Genetics; Computational biology; Genome; Cas9; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002229781,0.0001550518,0.0001638688,0.0001021066,0.0001805822,0.00006142039,0.000189662,0.00009858761,0.000004803368],"category_scores_gemma":[0.0003583583,0.0001371904,0.00009820281,0.0003750141,0.0001914028,0.00001519689,0.0001263046,0.00006362721,0.000005274773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005992461,"about_ca_system_score_gemma":0.00009505042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005704187,"about_ca_topic_score_gemma":0.00004550091,"domain_scores_codex":[0.998425,0.00003702315,0.0003849138,0.000550707,0.0002899742,0.0003123884],"domain_scores_gemma":[0.999155,0.00001076313,0.0002493598,0.0003996995,0.00008344381,0.000101708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007002908,0.00001413483,0.004230089,0.00001835092,0.000006636585,0.0003435226,0.00006117033,0.002729474,0.9909087,0.000002745171,0.001068114,0.0006100658],"study_design_scores_gemma":[0.00009608283,0.0001184361,0.07775962,0.0000284944,0.00002248885,0.000601329,0.00007418665,0.0006283331,0.8898473,0.00005662164,0.0305359,0.0002312404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966485,0.001093783,0.001160163,0.000144086,0.0004969282,0.0001768713,0.00001093752,0.00004678678,0.0002219344],"genre_scores_gemma":[0.9960044,0.0004925008,0.0002268248,0.0001130937,0.0001084402,0.00001460429,0.00006800402,0.00001868856,0.002953445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1010614,"threshold_uncertainty_score":0.5594463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02250562585009144,"score_gpt":0.2613986707754525,"score_spread":0.2388930449253611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}