{"id":"W4388365577","doi":"10.1016/j.ibneur.2023.08.459","title":"MELATONIN SYNERGISTICALLY POTENTIATES THE EFFECT OF METHYLPREDNISOLONE ON THE REDUCTION OF NEUROINFLAMMATION IN THE EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS (EAE) MOUSE MODEL OF MULTIPLE SCLEROSIS","year":2023,"lang":"en","type":"article","venue":"IBRO Neuroscience Reports","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"Experimental autoimmune encephalomyelitis; Multiple sclerosis; Neuroinflammation; Methylprednisolone; Encephalomyelitis; Medicine; Immunology; Inflammation; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000159715,0.0005221927,0.0006410246,0.0004595413,0.0001883135,0.0002392684,0.0002821763,0.0005037707,0.001780987],"category_scores_gemma":[0.0001512199,0.0001670771,0.0004558349,0.000220736,0.0002750947,0.000324663,0.0002117696,0.001140801,0.0003467896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002053782,"about_ca_system_score_gemma":0.0004062507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001278478,"about_ca_topic_score_gemma":0.003025746,"domain_scores_codex":[0.9998629,0.00002785807,0.00001561272,0.00001862657,0.00002793855,0.00004705555],"domain_scores_gemma":[0.9998745,0.00001056637,0.00002646398,0.0000118654,0.00001801045,0.00005860712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006224423,0.0008399958,0.0003790216,0.0003776271,0.00006734215,0.0001587463,0.00005502175,0.0001303404,0.9830133,0.0001051084,0.0004702556,0.008178748],"study_design_scores_gemma":[0.0008402976,0.01814088,0.01617172,0.0001002097,0.0003377016,0.0003350576,0.0001454707,0.001268981,0.9532655,0.0002763291,0.009074565,0.00004318839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985718,0.008916006,0.0009487944,0.0004926174,0.0003946507,0.00008342924,0.0006295213,0.0002845137,0.002532377],"genre_scores_gemma":[0.9908248,0.00392962,0.0009793516,0.0002096486,0.000102824,0.00008042344,0.0004821859,0.00002565991,0.003365522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001780987,"threshold_uncertainty_score":0.005958021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02713605620763736,"score_gpt":0.2533782021957907,"score_spread":0.2262421459881533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}