{"id":"W4388365577","doi":"10.1016/j.ibneur.2023.08.459","title":"MELATONIN SYNERGISTICALLY POTENTIATES THE EFFECT OF METHYLPREDNISOLONE ON THE REDUCTION OF NEUROINFLAMMATION IN THE EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS (EAE) MOUSE MODEL OF MULTIPLE SCLEROSIS","year":2023,"lang":"en","type":"article","venue":"IBRO Neuroscience Reports","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"Experimental autoimmune encephalomyelitis; Multiple sclerosis; Neuroinflammation; Methylprednisolone; Encephalomyelitis; Medicine; Immunology; Inflammation; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007599627,0.0001257307,0.000175519,0.0000493755,0.00009225161,0.0000140799,0.0003164613,0.00005423481,0.000001225991],"category_scores_gemma":[0.0008865245,0.00007107624,0.0001109165,0.0002587641,0.0005424561,0.000009848533,0.0001258897,0.00009461094,2.855029e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007319984,"about_ca_system_score_gemma":0.00003657515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004911597,"about_ca_topic_score_gemma":0.000001596997,"domain_scores_codex":[0.9985105,0.0002368461,0.0004570116,0.0003189823,0.0003008645,0.0001757805],"domain_scores_gemma":[0.9988461,0.000140444,0.0003763227,0.0005654411,0.00005195725,0.00001979267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005863889,0.00004171854,0.0006213883,0.00001414414,0.000004409229,0.000002044952,0.000224689,0.01368538,0.9851482,0.00005369402,0.00001822823,0.0001274577],"study_design_scores_gemma":[0.0001270301,0.0003204876,0.01659749,0.00002157626,0.00001040331,0.00001239917,0.0001347063,0.005480682,0.9771411,0.00008980834,0.00000437439,0.00005988768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990294,0.00008196625,0.0001385704,0.0001590573,0.0001263282,0.0003778016,0.00001708448,0.00000689081,0.00006292524],"genre_scores_gemma":[0.9997234,0.00008623758,0.00005095698,0.00001538825,0.00001825503,0.00004847641,0.00001349774,0.00001005052,0.00003379226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0159761,"threshold_uncertainty_score":0.2898405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02713605620763736,"score_gpt":0.2533782021957907,"score_spread":0.2262421459881533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}