{"id":"W4388373567","doi":"10.1101/2023.11.03.565335","title":"Target-agnostic identification of human antibodies to <i>Plasmodium falciparum</i> sexual forms reveals cross stage recognition of glutamate-rich repeats","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Malaria Research and Control","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Biological and Environmental Research; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health; French Infrastructure for Integrated Structural Biology; Wellcome Trust; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Agence Nationale de la Recherche; Natural Sciences and Engineering Research Council of Canada; Canadian Light Source; Hospital for Sick Children; Centre National de la Recherche Scientifique; University of California, San Francisco; Canadian Institute for Advanced Research; Office of Science; Bill and Melinda Gates Foundation; Brookhaven National Laboratory; Argonne National Laboratory; U.S. Department of Energy","keywords":"Biology; Plasmodium falciparum; Monoclonal antibody; Epitope; Gametocyte; Antibody; Antigen; Population; Genetics; Virology; Computational biology; Cell biology; Malaria; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001930671,0.0003599524,0.0001797327,0.0002089925,0.00009464367,0.0002322976,0.0002100661,0.0003308699,0.001958595],"category_scores_gemma":[0.0002093469,0.0001450177,0.000181901,0.0001198017,0.00008308327,0.0001145143,0.0002371077,0.0003400579,0.0007673886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002239946,"about_ca_system_score_gemma":0.00007555228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004198388,"about_ca_topic_score_gemma":0.000501757,"domain_scores_codex":[0.9997833,0.00003539085,0.00001222583,0.00006644119,0.00005445746,0.00004811821],"domain_scores_gemma":[0.9999278,0.0000179112,0.00001280823,0.000009855969,0.00002209533,0.000009643554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004022455,0.00001307832,0.0002885963,0.00001582242,0.000003596119,0.0000177007,0.000003757898,0.00005737221,0.9979248,0.00002260078,0.00007812202,0.001534348],"study_design_scores_gemma":[0.00001375817,0.0002513689,0.007272264,0.000005914359,0.00001692943,0.0005290869,0.00001343103,0.00248248,0.9866061,0.0000415197,0.002762303,0.000004951406],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9782084,0.0008587082,0.01597013,0.0001638256,0.00002616003,0.0001266645,0.0005853268,0.0002055039,0.003855423],"genre_scores_gemma":[0.9856687,0.0003681097,0.009436944,0.0002606823,0.00001436993,0.00005590082,0.001009087,0.00003648709,0.003149781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001958595,"threshold_uncertainty_score":0.006552219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03707592680057498,"score_gpt":0.3052003485626558,"score_spread":0.2681244217620808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}