{"id":"W4388379358","doi":"10.1016/j.jaci.2023.10.018","title":"JAK inhibitor treatment for inborn errors of JAK/STAT signaling: An ESID/EBMT-IEWP retrospective study","year":2023,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":61,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Medizinische Fakultät der Albert-Ludwigs-Universität Freiburg; Bundesministerium für Bildung, Wissenschaft, Forschung und Technologie; Istanbul Üniversitesi-Cerrahpasa; Lastentautien Tutkimussäätiö; Instituto de Salud Carlos III; Else Kröner-Fresenius-Stiftung; Kinderspital Zürich; Bundesministerium für Bildung und Forschung; Sanofi; Technische Universität Dresden; Deutsche Forschungsgemeinschaft","keywords":"stat; Medicine; JAK-STAT signaling pathway; Pharmacology; Cancer research; Oncology; Internal medicine; Signal transduction; Biology; Genetics; Receptor; Tyrosine kinase; STAT3","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003332416,0.000466299,0.0007578842,0.001037401,0.0005458845,0.0009562979,0.000373628,0.0006688439,0.002088686],"category_scores_gemma":[0.001199339,0.0005258479,0.001157474,0.001257787,0.0005679671,0.0006083237,0.0004613582,0.0009168307,0.0004773572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004657049,"about_ca_system_score_gemma":0.0005135684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001435994,"about_ca_topic_score_gemma":0.001170515,"domain_scores_codex":[0.9993513,0.00007114169,0.000128237,0.0002075799,0.0001080627,0.0001337178],"domain_scores_gemma":[0.9988655,0.0002852257,0.0004026368,0.0001475338,0.00009664951,0.0002024944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001257864,0.0002191319,0.9657032,0.00008324586,0.0004795817,0.02274601,0.0001561974,0.0001527561,0.001432299,0.0002247394,0.0003588112,0.007186108],"study_design_scores_gemma":[0.0002026908,0.001486145,0.8806751,0.000231451,0.001668773,0.1058016,0.001267929,0.000609319,0.001770573,0.0003838418,0.005822072,0.00008067205],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994003,0.003118671,0.0004397116,0.00007584978,0.00002478848,0.00002335252,0.0005585593,0.000006892426,0.001749062],"genre_scores_gemma":[0.9973448,0.001123806,0.0001993834,0.0001445439,0.00004015496,0.00001159432,0.0008023004,0.00001099936,0.0003224445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002088686,"threshold_uncertainty_score":0.006987393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04034285918337021,"score_gpt":0.3427059069663322,"score_spread":0.302363047782962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}