{"id":"W4388383236","doi":"10.1016/j.dnarep.2023.103591","title":"Telomeres as hotspots for innate immunity and inflammation","year":2023,"lang":"en","type":"article","venue":"DNA repair","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Hewitt Foundation; National Institute on Aging; Samuel Waxman Cancer Research Foundation; National Institute of General Medical Sciences; American Heart Association; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; European Molecular Biology Organization; Glenn Foundation for Medical Research; National Cancer Institute; National Institutes of Health; National Science Foundation","keywords":"Telomere; Biology; Inflammation; Innate immune system; Immunity; Senescence; Immunology; Permissive; Neuroscience; Genetics; Immune system; DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000374157,0.0001388939,0.000237816,0.0002230559,0.0001555966,0.00001920253,0.00008207632,0.00009793881,0.00003286501],"category_scores_gemma":[0.0005192088,0.0001232587,0.00009678608,0.0004074435,0.0001060079,0.0001172636,0.00007534493,0.0001229633,0.0001227733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003099944,"about_ca_system_score_gemma":0.000070824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001149455,"about_ca_topic_score_gemma":0.000025308,"domain_scores_codex":[0.9990098,0.00003589472,0.0002480059,0.0002483717,0.0001879962,0.0002699443],"domain_scores_gemma":[0.9991125,0.0001633781,0.00006630753,0.0004312856,0.0001001383,0.0001263962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.002075872,0.0002580524,0.1756552,0.002394397,0.000494652,0.0003921883,0.007621922,0.000006059721,0.3584872,0.006563766,0.03860545,0.4074452],"study_design_scores_gemma":[0.002468651,0.0005786324,0.7812946,0.0002237504,0.0001071197,0.0001015615,0.001109039,0.00328869,0.03952117,0.001891792,0.1690303,0.0003847291],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950829,0.0002994824,0.00001258271,0.001872087,0.0001675416,0.0005230855,0.00001287242,0.0007655888,0.001263916],"genre_scores_gemma":[0.9945942,0.0005266082,0.0007620008,0.0003416335,0.0001773864,0.00006975417,0.00009981304,0.00002957497,0.003399058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6056393,"threshold_uncertainty_score":0.5026343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02334003241290473,"score_gpt":0.297398092090955,"score_spread":0.2740580596780503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}