{"id":"W4388398374","doi":"10.1002/bies.202300145","title":"The eukaryotic translation initiation factor eIF4E unexpectedly acts in splicing thereby coupling mRNA processing with translation","year":2023,"lang":"en","type":"article","venue":"BioEssays","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"EIF4E; RNA splicing; Spliceosome; Biology; Splicing factor; Eukaryotic translation; Translation (biology); Messenger RNA; SR protein; Cell biology; Initiation factor; Genetics; Computational biology; RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003248959,0.0001339043,0.00009980327,0.00009669388,0.0002570138,0.00009677107,0.0001331987,0.0001072315,0.000005009562],"category_scores_gemma":[0.00004415143,0.00009423108,0.00003576142,0.0004518713,0.0000505011,0.00002208127,0.00001471892,0.0001331099,0.00001098633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002533446,"about_ca_system_score_gemma":0.0001142667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003402182,"about_ca_topic_score_gemma":0.0006064776,"domain_scores_codex":[0.998893,0.00004819297,0.0002081791,0.0002682258,0.000237899,0.0003444994],"domain_scores_gemma":[0.9995775,0.00006086612,0.00007180402,0.0001689489,0.00006676816,0.00005416356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001985958,0.00002081601,0.01425084,0.00004706341,0.00001852307,0.000005790688,0.0004803907,0.0022302,0.9426472,0.00002890043,0.00002002748,0.04005168],"study_design_scores_gemma":[0.004535784,0.0008576554,0.2670046,0.0005271474,0.00004366064,0.00001901591,0.003106509,0.2751787,0.4451348,0.0002641354,0.002308692,0.001019218],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947202,0.000673613,0.003151076,0.0004549163,0.00003800311,0.0003218981,0.000005676351,0.00004562574,0.0005890591],"genre_scores_gemma":[0.9991087,0.000280298,0.0001770218,0.00002423615,0.0001042574,0.00003220727,0.0001195409,0.00002857192,0.0001251072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4975123,"threshold_uncertainty_score":0.3842632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0389566310233523,"score_gpt":0.2945138226815516,"score_spread":0.2555571916581993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}