{"id":"W4388398374","doi":"10.1002/bies.202300145","title":"The eukaryotic translation initiation factor eIF4E unexpectedly acts in splicing thereby coupling mRNA processing with translation","year":2023,"lang":"en","type":"article","venue":"BioEssays","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"EIF4E; RNA splicing; Spliceosome; Biology; Splicing factor; Eukaryotic translation; Translation (biology); Messenger RNA; SR protein; Cell biology; Initiation factor; Genetics; Computational biology; RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004110376,0.0004002634,0.0002799015,0.0002158704,0.0002638944,0.0005151692,0.0001748342,0.0004109784,0.0006987163],"category_scores_gemma":[0.0003080994,0.0001673437,0.0003645565,0.0002724963,0.0004011054,0.0004585961,0.0003556198,0.0006102191,0.0004178331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002425088,"about_ca_system_score_gemma":0.0002655294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002238883,"about_ca_topic_score_gemma":0.0002998941,"domain_scores_codex":[0.9998178,0.00002769975,0.00002035111,0.00005943234,0.0000414383,0.00003327845],"domain_scores_gemma":[0.9998813,0.00003000504,0.00002417922,0.0000230615,0.00002231611,0.00001912916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003098144,0.00003628124,0.003709531,0.0003360698,0.0000386857,0.0007740911,0.00004000891,0.0004211043,0.9667714,0.003285397,0.0003897874,0.02388778],"study_design_scores_gemma":[0.00002796069,0.0002510716,0.01339596,0.00003141577,0.00005680113,0.002038058,0.00008031607,0.001168825,0.9490843,0.002353444,0.0314953,0.0000165247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8814149,0.04469615,0.05859672,0.002524478,0.001095258,0.00006653889,0.0008391534,0.0004752727,0.01029153],"genre_scores_gemma":[0.969413,0.01090433,0.01483901,0.0003400048,0.0001445893,0.00001757198,0.0005736522,0.00003431729,0.003733542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006987163,"threshold_uncertainty_score":0.002337456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0389566310233523,"score_gpt":0.2945138226815516,"score_spread":0.2555571916581993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}