{"id":"W4388405814","doi":"10.1101/2023.11.06.565206","title":"Novel DNA methylation changes in mouse lungs associated with heavy smoking","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital Research Institute of Manitoba; University of Manitoba","funders":"","keywords":"dNaM; DNA methylation; COPD; Carcinogenesis; Epigenome; Phenotype; Lung cancer; Biology; Lung; Nicotine; Immunology; Medicine; Gene; Bioinformatics; Genetics; Pathology; Gene expression; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002642595,0.0003634457,0.0002623399,0.001125487,0.0001775468,0.0002954308,0.000248702,0.0005328028,0.00199955],"category_scores_gemma":[0.0001636138,0.0003756117,0.0004316998,0.0004175802,0.0003596764,0.0001272664,0.0003208187,0.0005853369,0.0003010517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002667842,"about_ca_system_score_gemma":0.0001658268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00110766,"about_ca_topic_score_gemma":0.001814672,"domain_scores_codex":[0.9996986,0.00003774623,0.00001775172,0.0001226135,0.00008076572,0.00004253222],"domain_scores_gemma":[0.9997284,0.00003628422,0.0001203971,0.00003181215,0.00002777204,0.00005535923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009853589,0.00001161144,0.001487863,0.00002124404,0.00001290426,0.00004477057,0.00001670853,0.00005552172,0.9968677,0.00005789003,0.00004146979,0.001283711],"study_design_scores_gemma":[0.00003590513,0.0005880237,0.1210341,0.00002441024,0.0001104687,0.001383247,0.00010541,0.001842449,0.8703563,0.0003823795,0.004111419,0.00002586338],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.975186,0.002198697,0.01683578,0.0002031129,0.00004867759,0.00007466393,0.003424163,0.0004776017,0.00155125],"genre_scores_gemma":[0.9842801,0.001007617,0.008214949,0.0001699921,0.00001068401,0.0001338831,0.001861763,0.00009592745,0.00422498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00199955,"threshold_uncertainty_score":0.006689191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02277295760210059,"score_gpt":0.2398402382541531,"score_spread":0.2170672806520525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}