{"id":"W4388407365","doi":"10.1016/j.jacc.2023.08.053","title":"Multiomics Analysis Provides Novel Pathways Related to Progression of Heart Failure","year":2023,"lang":"en","type":"article","venue":"Journal of the American College of Cardiology","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; Servier; Vifor Pharma; National Medical Research Council; Cytokinetics; British Heart Foundation; Novo Nordisk; National Institute for Health and Care Research; FP7 Health; Impulse Dynamics; Ionis Pharmaceuticals; Boston Scientific Corporation; European Commission; Sanofi; MyoKardia; Universitair Medisch Centrum Groningen; AstraZeneca; ZonMw; Amgen","keywords":"Heart failure; Medicine; Cohort; Natriuretic peptide; PI3K/AKT/mTOR pathway; Ejection fraction; Internal medicine; Transcriptome; Oncology; Bioinformatics; Signal transduction; Biology; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007662926,0.0001128477,0.001433247,0.0005423427,0.00004510672,0.000002261678,0.0001612403,0.00007121357,0.000001664915],"category_scores_gemma":[0.0003699258,0.00006610465,0.00126388,0.002292886,0.0002300821,0.00002878949,0.000113348,0.000226283,0.000001177816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005744777,"about_ca_system_score_gemma":0.0002123509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009371242,"about_ca_topic_score_gemma":0.00000161364,"domain_scores_codex":[0.9984589,0.0001455119,0.0007228482,0.0001346337,0.0003544359,0.0001836825],"domain_scores_gemma":[0.9981172,0.0001619077,0.0008078478,0.0003220088,0.0004891111,0.0001019184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007477785,0.00005329358,0.1705496,0.00005894381,0.002958629,0.00002640769,0.0001567742,0.06283922,0.7544129,0.00005708493,0.007184554,0.0009547836],"study_design_scores_gemma":[0.003273986,0.00353155,0.9314068,0.0007416115,0.005431631,0.002080464,0.004314616,0.009670361,0.02692712,0.0001109077,0.01219811,0.0003128575],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943965,0.00009816505,0.000410415,0.004471824,0.0002132691,0.0002519921,0.0000784451,0.0000102272,0.00006918023],"genre_scores_gemma":[0.9921373,0.00005812052,0.007528177,0.00008940372,0.0001152667,0.000002465868,0.000002343093,0.00001531022,0.00005163408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7608572,"threshold_uncertainty_score":0.269567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0168954455533147,"score_gpt":0.2949572126387068,"score_spread":0.2780617670853921,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}