{"id":"W4388407365","doi":"10.1016/j.jacc.2023.08.053","title":"Multiomics Analysis Provides Novel Pathways Related to Progression of Heart Failure","year":2023,"lang":"en","type":"article","venue":"Journal of the American College of Cardiology","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; Servier; Vifor Pharma; National Medical Research Council; Cytokinetics; British Heart Foundation; Novo Nordisk; National Institute for Health and Care Research; FP7 Health; Impulse Dynamics; Ionis Pharmaceuticals; Boston Scientific Corporation; European Commission; Sanofi; MyoKardia; Universitair Medisch Centrum Groningen; AstraZeneca; ZonMw; Amgen","keywords":"Heart failure; Medicine; Cohort; Natriuretic peptide; PI3K/AKT/mTOR pathway; Ejection fraction; Internal medicine; Transcriptome; Oncology; Bioinformatics; Signal transduction; Biology; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007592454,0.000662341,0.0007707654,0.002121092,0.0004310964,0.001569371,0.0002542567,0.0004046821,0.002098337],"category_scores_gemma":[0.0009044493,0.0002053129,0.001053809,0.001415927,0.0002236502,0.0005076682,0.0007324863,0.0007359462,0.0002836537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003152051,"about_ca_system_score_gemma":0.0004594832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00115168,"about_ca_topic_score_gemma":0.002464694,"domain_scores_codex":[0.9995959,0.00008395618,0.00002806141,0.0001359301,0.00006979487,0.00008630657],"domain_scores_gemma":[0.9995158,0.000130887,0.0001696963,0.00003912233,0.00007522345,0.00006934391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003098442,0.0005676158,0.5942092,0.0005217688,0.00394001,0.0009065503,0.0002997265,0.004308149,0.2875733,0.002288963,0.003792097,0.09849424],"study_design_scores_gemma":[0.00005692403,0.0002666764,0.9653177,0.00005609936,0.0009847854,0.0006033882,0.0002291026,0.01330863,0.01151107,0.00406187,0.003552475,0.00005116847],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9651946,0.006455753,0.01594209,0.001282483,0.0001197139,0.00005339142,0.007836704,0.000226274,0.002889017],"genre_scores_gemma":[0.9865566,0.00136226,0.007170878,0.0003154774,0.0001236615,0.00004278339,0.003410927,0.00003990258,0.0009775234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002121092,"threshold_uncertainty_score":0.007019579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0168954455533147,"score_gpt":0.2949572126387068,"score_spread":0.2780617670853921,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}