{"id":"W4388408361","doi":"10.1371/journal.pgen.1011008","title":"PGP-14 establishes a polar lipid permeability barrier within the C. elegans pharyngeal cuticle","year":2023,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Biology; Cuticle (hair); Cell biology; Nematode; Xenobiotic; Nile red; Caenorhabditis elegans; Epithelium; Biochemistry; Anatomy; Genetics; Gene; Ecology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005430023,0.0003318771,0.0002491432,0.00006038457,0.0003602107,0.0001409434,0.0007214265,0.0002448562,0.00007890479],"category_scores_gemma":[0.0003178855,0.0002751625,0.0001637093,0.0003061641,0.0003282803,0.000008277955,0.0003931512,0.0002756832,0.0001581292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002587331,"about_ca_system_score_gemma":0.0001942251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002740109,"about_ca_topic_score_gemma":0.0002240903,"domain_scores_codex":[0.9976555,0.0002075873,0.0004063341,0.0006652534,0.0004406947,0.0006246463],"domain_scores_gemma":[0.9982408,0.00004779978,0.0001154016,0.001163894,0.0002073808,0.0002247423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005095752,0.0001939067,0.03289269,0.00007157329,0.0001729402,0.000008623533,0.002878838,0.002046291,0.9512317,0.0000681766,0.009879993,0.0005043336],"study_design_scores_gemma":[0.0006498509,0.0004328951,0.008738209,0.00001363797,0.0001670275,0.00002281798,0.0007996073,0.01191045,0.9433106,0.0006416185,0.03270407,0.0006092774],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961461,0.0008405182,0.0003353206,0.0008686911,0.0005538978,0.0004340473,0.0001139167,0.0001056882,0.0006018454],"genre_scores_gemma":[0.9955035,0.0003405176,0.0007271737,0.0009423976,0.0008645296,0.00004251568,0.000146689,0.00008636017,0.001346315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02415448,"threshold_uncertainty_score":0.9999701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0172805204229571,"score_gpt":0.2376735785836811,"score_spread":0.220393058160724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}