{"id":"W4388408505","doi":"10.1093/brain/awad375","title":"Caspase cleavage of gasdermin E causes neuronal pyroptosis in HIV-associated neurocognitive disorder","year":2023,"lang":"en","type":"article","venue":"Brain","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute; University of Alberta","funders":"National Institute of Mental Health; Faculty of Medicine and Dentistry, University of Alberta; Canadian Institutes of Health Research; National Institutes of Health; University of Alberta","keywords":"Pyroptosis; Caspase; Programmed cell death; Inflammasome; Apoptosis; Cell biology; Biology; Neurodegeneration; Caspase 3; Inflammation; Neuroscience; Immunology; Disease; Medicine; Pathology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009563618,0.0002353502,0.0001587935,0.0002343131,0.0001382048,0.0001890314,0.00009786619,0.0003040009,0.001060455],"category_scores_gemma":[0.0001115965,0.0001204802,0.0001827006,0.0001151137,0.0002439317,0.0001498784,0.0001690238,0.0004133805,0.0001673912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002036863,"about_ca_system_score_gemma":0.0001071264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004232168,"about_ca_topic_score_gemma":0.0006899504,"domain_scores_codex":[0.9999303,0.00001032106,0.000009410504,0.00001780637,0.00001334733,0.00001878594],"domain_scores_gemma":[0.9999558,0.00000668657,0.00001355032,0.000005810429,0.000005387494,0.00001271962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003492202,0.00006157241,0.002676553,0.0000527468,0.0000182692,0.001597707,0.0000384308,0.00005262325,0.9932609,0.00008213794,0.00004375483,0.001766188],"study_design_scores_gemma":[0.00007111827,0.001307807,0.1438971,0.00002730997,0.00006966447,0.02172174,0.0003165687,0.001034653,0.8290831,0.0004403951,0.002019259,0.00001121424],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998047,0.0006879669,0.0004869218,0.00002829741,0.000007809661,0.00001256786,0.00009964708,0.00001218498,0.0006176257],"genre_scores_gemma":[0.9984762,0.0004801808,0.0003898867,0.00002834697,0.000002586051,0.00001010598,0.0001245932,0.000002230023,0.000485929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001060455,"threshold_uncertainty_score":0.003547549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008039271416552196,"score_gpt":0.2412177313322395,"score_spread":0.2331784599156873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}