{"id":"W4388410095","doi":"10.21203/rs.3.rs-3527637/v1","title":"Physiologically Based RadioPharmacoKinetic (PBRPK) Modeling to Simulate and Analyze Radiopharmaceutical Therapies: Studies of Non-Linearities, Multi-Bolus Injections, and Albumin Binding","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Bolus (digestion); Albumin; Human albumin; Medicine; Pharmacology; Chemistry; Nuclear medicine; Biomedical engineering; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007581615,0.0009252407,0.00113649,0.0003638336,0.0003975848,0.001188374,0.001166591,0.001978902,0.00121091],"category_scores_gemma":[0.003019973,0.0005687236,0.001186962,0.0004928922,0.0007061869,0.0008407868,0.0006171374,0.001586266,0.000381108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001137262,"about_ca_system_score_gemma":0.001585936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007296092,"about_ca_topic_score_gemma":0.002337413,"domain_scores_codex":[0.9996074,0.000147242,0.00001985068,0.00005994141,0.0001253112,0.00004017013],"domain_scores_gemma":[0.9987282,0.0009181509,0.0001353957,0.00005483533,0.0001291203,0.00003428684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00004033884,0.00005222296,0.0002911749,0.0000595114,0.00002655258,0.00006234719,0.00004636923,0.9844766,0.007061266,0.00403642,0.0002538486,0.003593456],"study_design_scores_gemma":[0.000006177535,0.0000195541,0.00009275431,0.000002640682,0.000007387966,0.00002166409,0.000003667164,0.9975021,0.001570494,0.0004787461,0.0002901096,0.000004636],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.1152145,0.002043998,0.8696916,0.001023971,0.0002590103,0.0002473054,0.0002352542,0.0006638723,0.01062044],"genre_scores_gemma":[0.9021116,0.001813396,0.08404293,0.0004395616,0.0001138815,0.0004682528,0.0001992194,0.0004055268,0.01040556],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.007296092,"threshold_uncertainty_score":0.01450723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3599082267647525,"score_gpt":0.5441356761706961,"score_spread":0.1842274494059437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}