{"id":"W4388414441","doi":"10.1002/tox.24012","title":"6‐benzylaminopurine causes endothelial dysfunctions to human umbilical vein endothelial cells and exacerbates atorvastatin‐induced cerebral hemorrhage in zebrafish","year":2023,"lang":"en","type":"article","venue":"Environmental Toxicology","topic":"Zebrafish Biomedical Research Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Basic and Applied Basic Research Foundation of Guangdong Province; Natural Sciences and Engineering Research Council of Canada; Universidade de Macau; Canada Research Chairs; Baylor University","keywords":"Umbilical vein; Zebrafish; p38 mitogen-activated protein kinases; Phosphorylation; MAPK/ERK pathway; Pharmacology; Signal transduction; Cell biology; Western blot; Toxicity; Atorvastatin; Regulator; Endothelial dysfunction; Biology; In vitro; Chemistry; Toxicology; Medicine; Internal medicine; Biochemistry; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001630436,0.0004494538,0.0002988122,0.0002773707,0.0001971439,0.000181532,0.0001979787,0.0003445924,0.001233467],"category_scores_gemma":[0.0001074899,0.0001785258,0.0004706101,0.0001344859,0.0002384851,0.0002118928,0.0002209963,0.0007863839,0.0001645142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003410101,"about_ca_system_score_gemma":0.0003867696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00319098,"about_ca_topic_score_gemma":0.005515958,"domain_scores_codex":[0.9998443,0.00002439786,0.00001877323,0.00002635561,0.00004573867,0.00004032726],"domain_scores_gemma":[0.9999369,0.000005417347,0.00002184495,0.000006849259,0.00000982897,0.00001923935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002044735,0.00006811192,0.0003146137,0.00006216927,0.00001435867,0.0001554615,0.00003267618,0.00005466061,0.9981432,0.00008378077,0.00009719221,0.0007692105],"study_design_scores_gemma":[0.00004372828,0.001432036,0.01020915,0.00001351791,0.00005436402,0.0002550593,0.0000991674,0.001085771,0.9843642,0.0000767633,0.00235694,0.000009271868],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935144,0.001459026,0.002423532,0.0002975001,0.00008038867,0.0000525679,0.0003964759,0.0001216286,0.001654427],"genre_scores_gemma":[0.9928477,0.001264123,0.001084096,0.0001382795,0.00001267576,0.00007617233,0.0003521784,0.00001187976,0.004212919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00319098,"threshold_uncertainty_score":0.006344855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01509281311196246,"score_gpt":0.27326547437877,"score_spread":0.2581726612668075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}