{"id":"W4388414441","doi":"10.1002/tox.24012","title":"6‐benzylaminopurine causes endothelial dysfunctions to human umbilical vein endothelial cells and exacerbates atorvastatin‐induced cerebral hemorrhage in zebrafish","year":2023,"lang":"en","type":"article","venue":"Environmental Toxicology","topic":"Zebrafish Biomedical Research Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Basic and Applied Basic Research Foundation of Guangdong Province; Natural Sciences and Engineering Research Council of Canada; Universidade de Macau; Canada Research Chairs; Baylor University","keywords":"Umbilical vein; Zebrafish; p38 mitogen-activated protein kinases; Phosphorylation; MAPK/ERK pathway; Pharmacology; Signal transduction; Cell biology; Western blot; Toxicity; Atorvastatin; Regulator; Endothelial dysfunction; Biology; In vitro; Chemistry; Toxicology; Medicine; Internal medicine; Biochemistry; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002486549,0.0002401327,0.0002403535,0.0001839302,0.0001762071,0.00002997555,0.0002729241,0.0002451863,0.0004913687],"category_scores_gemma":[0.0001344746,0.0002569334,0.00006516957,0.0002286197,0.0003363045,0.00001006044,0.0005904962,0.000250667,0.0003939631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000991454,"about_ca_system_score_gemma":0.00005404794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005994509,"about_ca_topic_score_gemma":0.0004488892,"domain_scores_codex":[0.9978474,0.0001515005,0.0003417645,0.000740153,0.0002520572,0.0006671298],"domain_scores_gemma":[0.9990758,0.00009162424,0.00005316879,0.0003912368,0.000006326678,0.0003818452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006201443,0.0002787668,0.003973576,0.00001033983,0.0000209742,0.00003833087,0.000066723,0.00001134447,0.9919553,0.00009533469,0.001852585,0.00163474],"study_design_scores_gemma":[0.001647792,0.001242835,0.08746865,0.000004867687,0.00001089435,0.0000326045,0.0002332918,0.00007267122,0.88938,0.0002205281,0.01936491,0.0003209157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973186,0.00002080307,0.00005903184,0.0009764277,0.0001327129,0.0006641374,0.0004650838,0.00004638901,0.0003168501],"genre_scores_gemma":[0.9960846,0.00003649651,0.0003623005,0.0005815863,0.0002963624,0.0004127335,0.0003629516,0.00004938617,0.00181356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1025752,"threshold_uncertainty_score":0.9999883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01509281311196246,"score_gpt":0.27326547437877,"score_spread":0.2581726612668075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}