{"id":"W4388414685","doi":"10.1016/j.jid.2023.09.152","title":"144 Dupilumab restores the equilibrium of keratins and desmosomal components, integral components of the skin barrier cornified envelope","year":2023,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"Skin Protection and Aging","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Innovaderm (Canada)","funders":"","keywords":"Dupilumab; Filaggrin; Monoclonal antibody; Atopic dermatitis; Dermatology; Epidermis (zoology); Keratin; Medicine; Chemistry; Immunology; Antibody; Pathology; Anatomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009408477,0.0002905617,0.0003298341,0.0002805189,0.0003389153,0.0006339671,0.0002355404,0.0004041145,0.003757059],"category_scores_gemma":[0.0001569999,0.0001415999,0.000244156,0.0001220938,0.0001817968,0.0002909029,0.0001354305,0.0006778632,0.0009289936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003999698,"about_ca_system_score_gemma":0.0003072277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000828078,"about_ca_topic_score_gemma":0.0009337612,"domain_scores_codex":[0.9998719,0.00001739512,0.000009869997,0.00002265699,0.0000323005,0.00004591567],"domain_scores_gemma":[0.9999458,0.000007335267,0.000009551612,0.000008354161,0.00001178192,0.00001721283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002085338,0.0005948882,0.0005156043,0.0001463123,0.00002975743,0.0002126764,0.00003074238,0.0001298313,0.9497721,0.0004840182,0.001428821,0.04456993],"study_design_scores_gemma":[0.0002945909,0.002951531,0.008577179,0.00002201272,0.0000830398,0.002213995,0.0001313559,0.001402647,0.959364,0.0002241117,0.02471311,0.00002249259],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889176,0.003808924,0.001163143,0.0002780362,0.0002648985,0.00004033932,0.0002611289,0.0002027231,0.005063178],"genre_scores_gemma":[0.9930683,0.0008224353,0.0007733281,0.000138056,0.00003636345,0.00001879781,0.0002729978,0.00002381768,0.004845977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003757059,"threshold_uncertainty_score":0.01256859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04748211913229552,"score_gpt":0.2768247427025034,"score_spread":0.2293426235702079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}