{"id":"W4388415168","doi":"10.1016/j.jid.2023.09.086","title":"78 A Phase 2, randomized, placebo-controlled, dose-ranging study of oral JNJ-77242113 for moderate-to-severe plaque psoriasis: Efficacy of overall and scalp psoriasis responses from FRONTIER 1","year":2023,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Probity Medical Research; University of Toronto; McMaster University; Innovaderm (Canada)","funders":"","keywords":"Medicine; Psoriasis; Dose-ranging study; Plaque psoriasis; Dermatology; Scalp; Placebo; Internal medicine; Double blind; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001153061,0.001721325,0.00264719,0.0005951262,0.0004903731,0.0008177496,0.0009178035,0.001788252,0.009182307],"category_scores_gemma":[0.0008738796,0.0007239887,0.001442073,0.0003032977,0.0008804402,0.0006626066,0.0002223256,0.003272292,0.001614159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005595013,"about_ca_system_score_gemma":0.001102824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001119055,"about_ca_topic_score_gemma":0.003103476,"domain_scores_codex":[0.9995914,0.0001536717,0.00002072166,0.00007511537,0.00004509827,0.0001140886],"domain_scores_gemma":[0.999563,0.0001217496,0.0000624003,0.00003279737,0.00002976797,0.0001901707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9083424,0.02666982,0.00090366,0.0006682826,0.0008226314,0.00008872014,0.00007209775,0.0003813258,0.0178319,0.0001696222,0.002060513,0.04198905],"study_design_scores_gemma":[0.8782716,0.1172357,0.002121009,0.00002036537,0.0002814132,0.0000446364,0.00001598606,0.0001828249,0.0008428591,0.00007665418,0.0008888674,0.00001818137],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849339,0.00312929,0.0006747359,0.0005338081,0.0003963053,0.004058131,0.001485383,0.0001780055,0.004610424],"genre_scores_gemma":[0.9761836,0.003045925,0.0022582,0.002014075,0.0005295601,0.003408237,0.002442175,0.00006545371,0.0100527],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009182307,"threshold_uncertainty_score":0.03071785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03336834155924129,"score_gpt":0.2978408237311634,"score_spread":0.2644724821719222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}