{"id":"W4388415534","doi":"10.1016/j.jid.2023.09.085","title":"77 JNJ-77242113 treatment induces strong systemic pharmacodynamic response versus placebo in patients with plaque psoriasis: Results from the phase 2, FRONTIER 1 study","year":2023,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Innovaderm (Canada)","funders":"","keywords":"Psoriasis; Medicine; Placebo; Pharmacodynamics; Internal medicine; Gastroenterology; Randomized controlled trial; Plaque psoriasis; Pharmacokinetics; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001125241,0.0009875026,0.002354497,0.0004633642,0.0004145956,0.0008958124,0.0005410753,0.001114161,0.00454571],"category_scores_gemma":[0.0007173178,0.000445422,0.001390736,0.0003298768,0.0007192992,0.0005800027,0.0002254535,0.002199359,0.0008483721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000500329,"about_ca_system_score_gemma":0.000753046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008716534,"about_ca_topic_score_gemma":0.001902989,"domain_scores_codex":[0.9994824,0.0002398747,0.00002751689,0.00006151609,0.00005559694,0.0001330585],"domain_scores_gemma":[0.9995323,0.0001237027,0.00009223916,0.0000348931,0.00002712142,0.0001897282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7645234,0.05303978,0.004474891,0.0007998577,0.001562793,0.0003104575,0.000155869,0.0007324651,0.06515516,0.0001739422,0.002458256,0.1066133],"study_design_scores_gemma":[0.3434202,0.6264208,0.02258625,0.00004674916,0.0007072292,0.0002255206,0.00008819771,0.0004661207,0.004427676,0.0001272954,0.001440894,0.0000430846],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950495,0.001973606,0.0001802991,0.0002794989,0.0001446478,0.0004800526,0.0003411374,0.00006421116,0.001486953],"genre_scores_gemma":[0.9941154,0.001582209,0.0004879394,0.0005637368,0.0003166618,0.0003555526,0.0006303779,0.00002450229,0.001923572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00454571,"threshold_uncertainty_score":0.01520693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03767727716746607,"score_gpt":0.2889860757799174,"score_spread":0.2513087986124513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}