{"id":"W4388421127","doi":"10.1038/s41422-023-00893-1","title":"Cryo-EM structures of human SID-1 transmembrane family proteins and implications for their low-pH-dependent RNA transport activity","year":2023,"lang":"en","type":"letter","venue":"Cell Research","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Education and Child Care","funders":"National Key Research and Development Program of China; Institute of Biophysics, Chinese Academy of Sciences; ShanghaiTech University; Fundamental Research Funds for the Central Universities; Chinese Academy of Sciences; National Natural Science Foundation of China","keywords":"Transmembrane protein; RNA; Chemistry; Biophysics; Cell biology; Computational biology; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008900912,0.0003004744,0.0004127522,0.0002815413,0.0003546365,0.00005734514,0.0006814089,0.0007928752,0.00001354856],"category_scores_gemma":[0.0000599993,0.0002616128,0.0002260013,0.0002089765,0.000338141,0.000006291222,0.0001299964,0.001350931,0.000002611712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003914476,"about_ca_system_score_gemma":0.0003911073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003249632,"about_ca_topic_score_gemma":0.0002785805,"domain_scores_codex":[0.9972054,0.0002239385,0.0003123882,0.0008242822,0.0005522604,0.0008817415],"domain_scores_gemma":[0.998334,0.0001692836,0.00009187972,0.0008245746,0.0004168618,0.0001634257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001270919,0.00005128131,0.00005012532,0.001668292,0.00007110305,0.00001275174,0.00007522047,0.000005181603,0.9548416,0.00001119798,0.04005245,0.003033676],"study_design_scores_gemma":[0.0009013224,0.0008662356,0.005207434,0.000076187,0.00002240718,0.000003568182,0.0001140379,0.00001258042,0.9652557,0.0006437207,0.02655817,0.0003386102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.975447,0.0006887433,0.000525667,0.01913465,0.00004468986,0.002385853,0.00108843,0.00002177066,0.0006631859],"genre_scores_gemma":[0.9799488,0.0009818426,0.00007818119,0.001986723,0.001032333,0.0007424216,0.001334814,0.000152452,0.01374245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01714793,"threshold_uncertainty_score":0.9999836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06288043263849091,"score_gpt":0.3580008964242932,"score_spread":0.2951204637858023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}