{"id":"W4388422699","doi":"10.1128/spectrum.02157-23","title":"Alternative oxidase promotes high iron tolerance in <i>Candida albicans</i>","year":2023,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; Audrey and Theodor Geisel School of Medicine at Dartmouth; National Institute of Dental and Craniofacial Research; Concordia University; Dartmouth College; American Heart Association; Temple University; National Institutes of Health; RTI International","keywords":"Alternative oxidase; Reactive oxygen species; Mitochondrion; Oxidative stress; Oxidase test; Candida albicans; Corpus albicans; Biology; NADPH oxidase; Oxidative phosphorylation; Cell biology; Respiratory chain; Oxygen; Electron transport chain; Biochemistry; Chemistry; Microbiology; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002355457,0.0001797089,0.0003987041,0.0001447586,0.00005646002,0.000007620839,0.0001263633,0.0001357846,0.0003852325],"category_scores_gemma":[0.00007018156,0.0001508265,0.00008052304,0.0004185518,0.0002318135,0.00004566953,0.00005793209,0.0003001335,0.0004548937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001303959,"about_ca_system_score_gemma":0.00007981062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005636212,"about_ca_topic_score_gemma":0.001626327,"domain_scores_codex":[0.9985974,0.00007502599,0.0002756201,0.0004842237,0.00005742751,0.0005102794],"domain_scores_gemma":[0.9994426,0.00007789435,0.00006017974,0.0003212751,0.00002435497,0.00007364873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004689714,0.0001716019,0.1789535,0.00007547021,0.00002999739,0.0004139277,0.0003058495,0.00001639047,0.8159354,0.0005767327,0.002573988,0.0004781846],"study_design_scores_gemma":[0.003880313,0.0008320117,0.7012885,0.0002430127,0.0000418476,0.0001233674,0.0002250754,0.0001706153,0.281528,0.003401647,0.00779703,0.0004685474],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938455,0.0001928148,0.0000361896,0.004151874,0.0002322807,0.0003885247,0.00006507415,0.0001179527,0.0009697587],"genre_scores_gemma":[0.995575,0.0001016658,0.0001039789,0.0008043299,0.0001318421,0.0000213299,0.0001557379,0.00001878029,0.003087401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5344074,"threshold_uncertainty_score":0.6150528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009905638907953485,"score_gpt":0.2558037137304937,"score_spread":0.2458980748225402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}