{"id":"W4388422699","doi":"10.1128/spectrum.02157-23","title":"Alternative oxidase promotes high iron tolerance in <i>Candida albicans</i>","year":2023,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; Audrey and Theodor Geisel School of Medicine at Dartmouth; National Institute of Dental and Craniofacial Research; Concordia University; Dartmouth College; American Heart Association; Temple University; National Institutes of Health; RTI International","keywords":"Alternative oxidase; Reactive oxygen species; Mitochondrion; Oxidative stress; Oxidase test; Candida albicans; Corpus albicans; Biology; NADPH oxidase; Oxidative phosphorylation; Cell biology; Respiratory chain; Oxygen; Electron transport chain; Biochemistry; Chemistry; Microbiology; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001408491,0.000308714,0.0002222402,0.0002051113,0.0001813507,0.000470692,0.0002995372,0.0002775937,0.00135064],"category_scores_gemma":[0.0001293877,0.0001024097,0.0002834242,0.0001745452,0.0001833643,0.0001372273,0.0002754253,0.0006793967,0.0003131605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002628857,"about_ca_system_score_gemma":0.0002012475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001051187,"about_ca_topic_score_gemma":0.0008821044,"domain_scores_codex":[0.9997732,0.00002776926,0.00002447681,0.0000486617,0.00006920788,0.00005672249],"domain_scores_gemma":[0.9998384,0.00001391713,0.00004788134,0.00001931954,0.00003664174,0.00004382452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007056597,0.00003243966,0.0002065526,0.0000230313,0.000002760446,0.00005974999,0.00000772773,0.00001501963,0.9990557,0.00004477915,0.00007271313,0.0004089164],"study_design_scores_gemma":[0.00001481987,0.0002537407,0.01515117,0.00001690475,0.00001548663,0.0005125645,0.00009415666,0.001182143,0.9803789,0.00008282626,0.00228412,0.00001305825],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963847,0.000495191,0.001185033,0.0001490974,0.00004376508,0.00002385394,0.00053169,0.00009536535,0.001091314],"genre_scores_gemma":[0.9963301,0.0001783724,0.001105208,0.0000834783,0.000009557094,0.00002084962,0.0005693478,0.00002088136,0.001682227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00135064,"threshold_uncertainty_score":0.00451833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009905638907953485,"score_gpt":0.2558037137304937,"score_spread":0.2458980748225402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}