{"id":"W4388447382","doi":"10.1093/gerona/glad254","title":"Differences in Alzheimer’s Disease–Related Pathology Profiles Across Apolipoprotein Groups","year":2023,"lang":"en","type":"article","venue":"The Journals of Gerontology Series A","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University; Douglas Mental Health University Institute; Carleton University","funders":"Fonds de Recherche du Québec - Santé; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; DoD Alzheimer's Disease Neuroimaging Initiative; BioClinica; Biogen; Pfizer; Novartis Pharmaceuticals Corporation; Garfield Weston Foundation; University of Southern California; Alzheimer Society; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Fondation Brain Canada; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; National Institute on Aging; Alzheimer Society Research Program; Alzheimer's Association","keywords":"Disease; Apolipoprotein E; Apolipoprotein B; Alzheimer's disease; Medicine; Pathology; Biology; Computational biology; Internal medicine; Cholesterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002100597,0.0003205234,0.0004703713,0.0007340047,0.0003452423,0.0006993518,0.0003619294,0.000397194,0.002132765],"category_scores_gemma":[0.005583906,0.0001849444,0.0006495664,0.0004635394,0.0003242374,0.0005230306,0.0003904538,0.0002877775,0.0004206682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002636513,"about_ca_system_score_gemma":0.0002265343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003844875,"about_ca_topic_score_gemma":0.004722446,"domain_scores_codex":[0.9990112,0.0002838691,0.000129182,0.0002544445,0.0002041061,0.000117179],"domain_scores_gemma":[0.9979833,0.0007251445,0.0005409265,0.0002694501,0.0002580849,0.0002230637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004740802,0.0003874706,0.953046,0.0001089779,0.001577384,0.0004321024,0.001708657,0.0001535777,0.008889284,0.0006847763,0.001002461,0.02726852],"study_design_scores_gemma":[0.00002926508,0.0002994356,0.9974475,0.000017201,0.00008811731,0.0001694692,0.0003881166,0.0001634274,0.000270053,0.0006676792,0.0004495106,0.00001034296],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968531,0.0004899518,0.0004819125,0.00009859705,0.00002039603,0.0000386699,0.0002945381,0.00001309246,0.001709731],"genre_scores_gemma":[0.9978003,0.0001578045,0.0004655691,0.00008570885,0.00001052376,0.00004458328,0.0004603301,0.00001086584,0.0009643712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003844875,"threshold_uncertainty_score":0.01110917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09375031171268819,"score_gpt":0.3769455852676713,"score_spread":0.2831952735549831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}