{"id":"W4388448664","doi":"10.1016/j.euo.2023.10.008","title":"Pembrolizumab and Enzalutamide in Patients with Abiraterone Acetate–Pretreated Metastatic Castration-Resistant Prostate Cancer: Cohort C of the Phase 1b/2 KEYNOTE-365 Study","year":2023,"lang":"en","type":"article","venue":"European Urology Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Western University","funders":"","keywords":"Enzalutamide; Medicine; Prostate cancer; Abiraterone acetate; Pembrolizumab; Internal medicine; Oncology; Cohort; Interquartile range; Adverse effect; Clinical endpoint; Androgen deprivation therapy; Cancer; Clinical trial; Androgen receptor; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006129117,0.0002330313,0.0005674788,0.0002609937,0.0001136508,0.00001066625,0.0001461873,0.00004890332,0.00003809395],"category_scores_gemma":[0.00007804168,0.0001395301,0.00003792212,0.0006435946,0.0005033676,0.00006144447,0.0001376046,0.0003418857,0.00002051084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000170902,"about_ca_system_score_gemma":0.0003494901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002091534,"about_ca_topic_score_gemma":0.0005889733,"domain_scores_codex":[0.9972156,0.00108669,0.0004728962,0.0004718606,0.0002861773,0.00046678],"domain_scores_gemma":[0.9990085,0.0001421462,0.000205199,0.0003510615,0.0001751994,0.0001178365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01759114,0.002923073,0.9666942,0.00007056316,0.000524418,0.001230538,0.002992821,0.0001097255,0.002333264,0.000007392548,0.0001887573,0.005334054],"study_design_scores_gemma":[0.05103817,0.01320769,0.9340544,0.00002785619,0.0003930281,0.0000204594,0.0003188402,0.00008317509,0.0003184075,0.00001163033,0.0004136362,0.0001127611],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951327,0.0002629322,7.524714e-7,0.0009293513,0.0001256589,0.002562611,0.00007422784,0.00005155272,0.000860154],"genre_scores_gemma":[0.9985074,0.0001561722,0.00002051602,0.0001518273,0.00001986009,0.0001429916,0.00009211204,0.00004766659,0.0008613929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03344703,"threshold_uncertainty_score":0.5689873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02421598996196259,"score_gpt":0.3315793593632952,"score_spread":0.3073633694013327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}