{"id":"W4388451152","doi":"10.1210/endocr/bqad164","title":"TSH Pulses Finely Tune Thyroid Hormone Release and TSH Receptor Transduction","year":2023,"lang":"en","type":"article","venue":"Endocrinology","topic":"Thyroid Disorders and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México; Canadian Institutes of Health Research; National Institute of Diabetes and Digestive and Kidney Diseases; College of Natural Resources and Sciences, Humboldt State University; Centre National de la Recherche Scientifique; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; British Society for Neuroendocrinology; Université de Montpellier; Wellcome Trust","keywords":"Endocrinology; Internal medicine; Thyroid; Thyroid-stimulating hormone; Ultradian rhythm; Hormone; Medicine; Population; Biology; Circadian rhythm","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003563151,0.0003074346,0.0002149572,0.0002809627,0.0001373828,0.0006213638,0.0002977764,0.0003291728,0.001165661],"category_scores_gemma":[0.0003650822,0.000255238,0.0003590576,0.0001220415,0.0004515761,0.000388285,0.0004704895,0.0006742721,0.0003269123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000367403,"about_ca_system_score_gemma":0.0002218507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004509801,"about_ca_topic_score_gemma":0.000931948,"domain_scores_codex":[0.9997405,0.00003326563,0.0000206458,0.00006180428,0.0000854956,0.00005834287],"domain_scores_gemma":[0.9998153,0.00005545261,0.00004159971,0.00002648271,0.00002450404,0.00003662182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005227121,0.000008992477,0.0003229875,0.00001834733,0.000002730181,0.00001630554,0.00001631005,0.00003362886,0.9976285,0.000135689,0.00004310626,0.001721167],"study_design_scores_gemma":[0.00001864794,0.0003126063,0.008799102,0.00001289022,0.0000162109,0.0002263706,0.0000681953,0.001621214,0.9848732,0.0002618535,0.003776503,0.00001320048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9525688,0.003094486,0.03908497,0.0003748807,0.0001875444,0.00009851392,0.0006363494,0.0006189246,0.00333554],"genre_scores_gemma":[0.9823433,0.001196715,0.01289004,0.0002370975,0.00003124868,0.00008019363,0.0003802417,0.00007641264,0.002764866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001165661,"threshold_uncertainty_score":0.003899515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01745314399482135,"score_gpt":0.2681715814132732,"score_spread":0.2507184374184518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}