{"id":"W4388451947","doi":"10.1158/2643-3230.bcd-23-0061","title":"ETV4-Dependent Transcriptional Plasticity Maintains <i>MYC</i> Expression and Results in IMiD Resistance in Multiple Myeloma","year":2023,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"National Cancer Institute; Paula and Rodger Riney Foundation; American Society of Hematology; Multiple Myeloma Research Foundation","keywords":"Transcription factor; Enhancer; Chromatin immunoprecipitation; Chromatin; Biology; Cancer research; Genetics; Promoter; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001031327,0.0002344962,0.0001980518,0.0001682194,0.0001567468,0.0002916071,0.0002434679,0.0002568227,0.001690507],"category_scores_gemma":[0.0001080366,0.0001194504,0.0003234186,0.0001444019,0.0002120264,0.0001666769,0.0002226413,0.0006890443,0.0004310037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005298536,"about_ca_system_score_gemma":0.0001406048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005415528,"about_ca_topic_score_gemma":0.0006707896,"domain_scores_codex":[0.999867,0.00001586561,0.00001143047,0.00003806901,0.00003410705,0.00003349888],"domain_scores_gemma":[0.9999368,0.000009572609,0.00002341268,0.0000113732,0.000007055183,0.00001185155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005489777,0.00001252011,0.0002748016,0.0000169325,0.000004170867,0.00002194243,0.000004796538,0.0001062759,0.9980485,0.0000587351,0.0000450473,0.001351308],"study_design_scores_gemma":[0.000009339163,0.00007177755,0.004498675,0.000002981366,0.00001053594,0.0002336595,0.00001371538,0.001000606,0.9913584,0.00005425019,0.002742857,0.000003236884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905143,0.00147742,0.005207317,0.0001443186,0.00004067924,0.00002290978,0.0007720108,0.0002646277,0.001556322],"genre_scores_gemma":[0.9939421,0.00037089,0.001530801,0.00006104816,0.000006016418,0.00001890228,0.0008865457,0.00004623388,0.003137367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001690507,"threshold_uncertainty_score":0.005655289,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02987792591273875,"score_gpt":0.2922991076502167,"score_spread":0.2624211817374779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}