{"id":"W4388452739","doi":"10.3390/brainsci13111562","title":"Mechanisms of Sustained Increases in γ Power Post-Ketamine in a Computational Model of the Hippocampal CA3: Implications for Ketamine’s Antidepressant Mechanism of Action","year":2023,"lang":"en","type":"article","venue":"Brain Sciences","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Dalhousie University","funders":"Research Nova Scotia; Nova Scotia Health Research Foundation","keywords":"Disinhibition; Ketamine; Neuroscience; Glutamatergic; Hippocampal formation; Long-term potentiation; Psychology; Electroencephalography; Excitatory postsynaptic potential; Antidepressant; LTP induction; Hippocampus; Medicine; Glutamate receptor; Inhibitory postsynaptic potential; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001270207,0.0001043935,0.0002211359,0.0006407421,0.0001608525,0.00001468591,0.0007914574,0.00004195692,0.000008609073],"category_scores_gemma":[0.002676615,0.00007812062,0.00007690419,0.002921384,0.0008480999,0.0002601725,0.0002280521,0.000104611,6.688762e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000216513,"about_ca_system_score_gemma":0.0004242467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007120443,"about_ca_topic_score_gemma":0.00004940278,"domain_scores_codex":[0.9980183,0.0002615617,0.0004294492,0.0004377782,0.0005107399,0.0003422025],"domain_scores_gemma":[0.997494,0.001898871,0.0002329739,0.000190088,0.0001407255,0.00004334152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004554356,0.0001840049,0.001273625,0.00002864333,7.74853e-7,0.000001403868,0.0001365884,0.01277733,0.9359954,0.04942328,0.00002708728,0.0001063333],"study_design_scores_gemma":[0.0005767362,0.0002803557,0.04995852,0.00002219833,0.000003372365,0.000006921412,0.0003511997,0.1835754,0.7094386,0.05570805,0.000001253683,0.00007740549],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936906,0.000003349558,0.001810983,0.003495771,0.0000852727,0.0006958829,0.0001529831,0.00001602609,0.00004912788],"genre_scores_gemma":[0.9992025,0.00001248444,0.0002144505,0.000405044,0.000002954328,0.00006505458,0.000001134643,0.000007266872,0.00008903533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2265568,"threshold_uncertainty_score":0.3204351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1116451252414416,"score_gpt":0.3913258455700528,"score_spread":0.2796807203286112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}