{"id":"W4388453540","doi":"10.1021/acschembio.3c00475","title":"One-Step Selective Labeling of Native Cell Surface Sialoglycans by Exogenous α2,8-Sialylation","year":2023,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canada Foundation for Innovation; Social Sciences and Humanities Research Council of Canada; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Glycan; Glycoconjugate; Chemistry; Biochemistry; Epitope; Sialyltransferase; Biotinylation; Enzyme; Cell; Glycoprotein; Biotin; Biology; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002214042,0.0006214139,0.0003739277,0.000122453,0.0001291445,0.0003399664,0.0002408922,0.0003028949,0.0006552665],"category_scores_gemma":[0.000153934,0.0001808182,0.000246397,0.0001819151,0.0002690928,0.000211683,0.000384547,0.0006234326,0.0005042235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003708696,"about_ca_system_score_gemma":0.0002914659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005990409,"about_ca_topic_score_gemma":0.001178987,"domain_scores_codex":[0.999854,0.00001893749,0.000009486873,0.00003415214,0.00004663635,0.00003675707],"domain_scores_gemma":[0.9999232,0.00001619577,0.00001650428,0.00001662814,0.00001418149,0.00001334293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001459985,0.000005503536,0.00004097984,0.00002200256,0.000001880139,0.0000133388,0.000006850189,0.00002929435,0.9991013,0.00005564655,0.00001282508,0.0006957464],"study_design_scores_gemma":[0.000001686723,0.00003143134,0.0002179619,0.000001346025,0.000002350414,0.00003044389,0.00000506853,0.0002298449,0.9987053,0.00001664232,0.0007559524,0.000002034153],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9351315,0.001354111,0.05872885,0.0001425155,0.00007691506,0.0001437807,0.0005339977,0.0002715421,0.003616784],"genre_scores_gemma":[0.9520988,0.002033917,0.03899136,0.0001108182,0.0000139633,0.0001583657,0.0008974861,0.00006917746,0.005626073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006552665,"threshold_uncertainty_score":0.002690911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01660126219254449,"score_gpt":0.281521704609598,"score_spread":0.2649204424170535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}