{"id":"W4388453540","doi":"10.1021/acschembio.3c00475","title":"One-Step Selective Labeling of Native Cell Surface Sialoglycans by Exogenous α2,8-Sialylation","year":2023,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canada Foundation for Innovation; Social Sciences and Humanities Research Council of Canada; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Glycan; Glycoconjugate; Chemistry; Biochemistry; Epitope; Sialyltransferase; Biotinylation; Enzyme; Cell; Glycoprotein; Biotin; Biology; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002466156,0.0001482884,0.0002237643,0.00005855606,0.00006311671,0.000007184005,0.0002280316,0.0003712487,0.00003190083],"category_scores_gemma":[0.0003020811,0.00015237,0.0000721812,0.0003953026,0.0001739543,0.00000394893,0.00016384,0.0001780661,0.00005391465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003063872,"about_ca_system_score_gemma":0.00009363528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009811981,"about_ca_topic_score_gemma":0.00001521126,"domain_scores_codex":[0.9986624,0.0001226153,0.0002740441,0.0004223456,0.0001405002,0.0003780976],"domain_scores_gemma":[0.999237,0.00008604753,0.0001115625,0.0002316958,0.0002481346,0.00008556479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001420448,0.00008202896,0.001039582,0.00001843991,0.00004894407,6.910758e-7,0.00007792625,0.00003576344,0.9952646,0.00007387455,0.001926521,0.001289552],"study_design_scores_gemma":[0.0006532004,0.0002802606,0.00009644873,0.000004717074,0.000009145566,0.000001160839,0.00005413965,0.0001157311,0.9924852,0.0002336718,0.005906924,0.0001594202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996172,0.0003119115,0.0007254507,0.0002248062,0.00005518063,0.0002855668,0.0001272589,0.00003455272,0.00206332],"genre_scores_gemma":[0.9968492,0.0002103914,0.0007738932,0.00008990277,0.00008885772,0.00002144562,0.001427308,0.0000220704,0.0005169444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003980402,"threshold_uncertainty_score":0.6213467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01660126219254449,"score_gpt":0.281521704609598,"score_spread":0.2649204424170535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}