{"id":"W4388456067","doi":"10.1038/s41467-023-41954-8","title":"Transcriptional reprogramming by mutated IRF4 in lymphoma","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Medical Research Council; Canadian Institutes of Health Research; Max-Planck-Gesellschaft; Deutsche Forschungsgemeinschaft; Natural Sciences and Engineering Research Council of Canada; Deutsche Krebshilfe; Wilhelm Sander-Stiftung; European Commission; Government of Canada; Kay Kendall Leukaemia Fund","keywords":"Reprogramming; IRF4; Lymphoma; Cancer research; Genetics; Transcription factor; Biology; Computational biology; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001181237,0.0001619684,0.0001328928,0.0001868591,0.00008644481,0.0001537944,0.0001391954,0.0002672794,0.0008587962],"category_scores_gemma":[0.0001382351,0.00007224669,0.0001619581,0.0000958969,0.0002000325,0.00007738328,0.0001378889,0.000209394,0.0001783317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000222692,"about_ca_system_score_gemma":0.00009468158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002819486,"about_ca_topic_score_gemma":0.0002315098,"domain_scores_codex":[0.9999089,0.00002396259,0.00000682424,0.00001741587,0.00002052375,0.00002234096],"domain_scores_gemma":[0.9999642,0.000007454692,0.00001067248,0.000006830002,0.000002793013,0.000007962032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002043432,0.00003747451,0.001767107,0.00001830969,0.000008092737,0.0009360223,0.0000187839,0.0001509644,0.9910897,0.0002454716,0.0000789215,0.005444805],"study_design_scores_gemma":[0.00009201989,0.0006650969,0.01946346,0.000009901771,0.0000544585,0.0131555,0.00007321681,0.002507376,0.9577895,0.000605701,0.005574971,0.000008766721],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967824,0.0007695352,0.001193063,0.00009201127,0.00001336599,0.000008266085,0.00006058644,0.00008345099,0.0009974489],"genre_scores_gemma":[0.9990465,0.0001739733,0.0003306909,0.00002963139,0.000004499609,0.000003428395,0.00005803493,0.000007597368,0.0003455608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008587962,"threshold_uncertainty_score":0.002872944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02713913260647286,"score_gpt":0.3328859233356521,"score_spread":0.3057467907291792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}