{"id":"W4388457940","doi":"10.15252/emmm.202317928","title":"Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy","year":2023,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Biomedical Research Council; National Medical Research Council; Medical Research Council; Diabetes UK; Agency for Science, Technology and Research; Wellcome Trust","keywords":"PAX6; Islet; Beta cell; Transplantation; PDX1; Glucose homeostasis; Biology; Diabetes mellitus; Cancer research; BETA (programming language); Endocrinology; Internal medicine; Cell biology; Medicine; Immunology; Gene; Insulin resistance; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002861311,0.0004120755,0.0004977498,0.0003061062,0.0001213056,0.0004830675,0.0003092551,0.000429461,0.002311523],"category_scores_gemma":[0.0001672994,0.0001123709,0.0002772184,0.0001694807,0.0002630492,0.0005420519,0.0002452563,0.001023509,0.0004629507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009877355,"about_ca_system_score_gemma":0.0001128927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000515534,"about_ca_topic_score_gemma":0.00006577025,"domain_scores_codex":[0.9998513,0.00002048544,0.00001842939,0.00002673642,0.00005320343,0.00002980187],"domain_scores_gemma":[0.9998293,0.00002827122,0.00004664316,0.00002545134,0.00001200673,0.00005828137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004985343,0.0002633814,0.0002648269,0.00008144328,0.00001601222,0.0001083293,0.00002314012,0.0002080997,0.987805,0.0002456512,0.0001054753,0.01038009],"study_design_scores_gemma":[0.0001346908,0.003271032,0.004700945,0.00002606827,0.0000869283,0.0008139975,0.00005121102,0.001366185,0.985198,0.0003089253,0.004030416,0.00001168635],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900402,0.001935521,0.004712261,0.0001625887,0.0001263378,0.0000328011,0.0002184732,0.0002729173,0.002498841],"genre_scores_gemma":[0.9930161,0.001597175,0.002521263,0.00008700828,0.00004747289,0.00002192972,0.0003397152,0.000072192,0.002297183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002311523,"threshold_uncertainty_score":0.007732809,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01514459623530717,"score_gpt":0.2477707837095979,"score_spread":0.2326261874742908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}