{"id":"W4388457940","doi":"10.15252/emmm.202317928","title":"Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy","year":2023,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Biomedical Research Council; National Medical Research Council; Medical Research Council; Diabetes UK; Agency for Science, Technology and Research; Wellcome Trust","keywords":"PAX6; Islet; Beta cell; Transplantation; PDX1; Glucose homeostasis; Biology; Diabetes mellitus; Cancer research; BETA (programming language); Endocrinology; Internal medicine; Cell biology; Medicine; Immunology; Gene; Insulin resistance; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000286953,0.0001977572,0.0003962929,0.0002222911,0.00007001298,0.00001115551,0.00006617771,0.00009753086,0.0001391132],"category_scores_gemma":[0.000160534,0.0001548895,0.0000710289,0.000369738,0.0001478887,0.00005924864,0.00002512862,0.0001322719,0.00006342039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001673588,"about_ca_system_score_gemma":0.00004337579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007263252,"about_ca_topic_score_gemma":0.000001331264,"domain_scores_codex":[0.9986283,0.00007106562,0.0002970183,0.0003413178,0.0003743558,0.0002879774],"domain_scores_gemma":[0.9991418,0.0001829152,0.00006252521,0.0002986349,0.00007387053,0.0002402838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001705379,0.00005013672,0.0005110272,0.0002723267,0.0001307004,0.000310622,0.0005596977,0.00001303496,0.9870341,0.00006365518,0.006715425,0.00416876],"study_design_scores_gemma":[0.009225319,0.001145248,0.1017266,0.000466989,0.0009249843,0.0000819503,0.0003659163,0.00229023,0.8764618,0.00016256,0.006849735,0.0002986352],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897848,0.001918916,0.0005573246,0.004452869,0.0002647859,0.0004393189,0.00001377562,0.0002377751,0.00233038],"genre_scores_gemma":[0.9932343,0.001313388,0.0006364672,0.002571511,0.0002637945,0.00002987558,0.0003830181,0.00003922932,0.001528382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1105722,"threshold_uncertainty_score":0.6316211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01514459623530717,"score_gpt":0.2477707837095979,"score_spread":0.2326261874742908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}