{"id":"W4388461198","doi":"10.1016/j.jneuroim.2023.578240","title":"Early life stress aggravates disease pathogenesis in mice with experimental autoimmune encephalomyelitis: Support for a two-hit hypothesis of multiple sclerosis etiology","year":2023,"lang":"en","type":"article","venue":"Journal of Neuroimmunology","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; University of Lethbridge","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates; Alberta Innovates - Health Solutions","keywords":"Experimental autoimmune encephalomyelitis; Multiple sclerosis; Etiology; Pathogenesis; Encephalomyelitis; Disease; Medicine; Autoimmune disease; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003491416,0.0008682469,0.0005686363,0.0007579647,0.000240211,0.0004413488,0.0002424539,0.0005796338,0.00124344],"category_scores_gemma":[0.0002946853,0.0002262246,0.0004831465,0.0002126707,0.000522679,0.0003662963,0.000452046,0.001556913,0.0001624219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002608538,"about_ca_system_score_gemma":0.0002313564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002776215,"about_ca_topic_score_gemma":0.0006718824,"domain_scores_codex":[0.9996598,0.00008713907,0.00002651356,0.0000636531,0.00006518944,0.00009783481],"domain_scores_gemma":[0.9993327,0.0000613431,0.0002138403,0.00008631084,0.00004774512,0.0002579775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001233402,0.0001627856,0.002730182,0.00005804538,0.00002803277,0.0003494764,0.000074746,0.00003667358,0.9937033,0.0001172916,0.00005415731,0.001451825],"study_design_scores_gemma":[0.000207866,0.00567583,0.2594113,0.00007504724,0.0002053366,0.002853477,0.0007378555,0.001257145,0.7263397,0.001235119,0.001924764,0.00007670269],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961106,0.001358766,0.001434024,0.0002720054,0.00007913953,0.00002110732,0.0002053671,0.00006578233,0.0004532691],"genre_scores_gemma":[0.9965894,0.001049417,0.001052586,0.0001156622,0.00003997963,0.00003508815,0.00014879,0.00001661113,0.0009524065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00124344,"threshold_uncertainty_score":0.004159749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06204369820892335,"score_gpt":0.2763957979609848,"score_spread":0.2143520997520614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}