{"id":"W4388461381","doi":"10.1016/j.ctrv.2023.102653","title":"Pharmacotherapy for leptomeningeal disease in breast cancer","year":2023,"lang":"en","type":"article","venue":"Cancer Treatment Reviews","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"Seagen","keywords":"Medicine; Breast cancer; Trastuzumab; Clinical trial; Oncology; Metastatic breast cancer; Systemic therapy; Cancer; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000435396,0.0001564508,0.0005502889,0.0006203927,0.0001366394,0.0003961265,0.0002306454,0.0002834896,0.001750299],"category_scores_gemma":[0.0008746518,0.00006735443,0.0005027913,0.0005399447,0.000140869,0.000225535,0.0002264961,0.0005271625,0.0003667288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004457165,"about_ca_system_score_gemma":0.0004980583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000512689,"about_ca_topic_score_gemma":0.002082098,"domain_scores_codex":[0.9997472,0.0001246358,0.00003609556,0.00002517071,0.00004538092,0.00002151122],"domain_scores_gemma":[0.9997842,0.0001074799,0.00006118912,0.00000949355,0.00002560788,0.00001212653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00120722,0.0002305683,0.002249582,0.01513951,0.0007583142,0.0005033006,0.00007433177,0.0005492809,0.005489099,0.001607521,0.01665484,0.9555365],"study_design_scores_gemma":[0.003054357,0.004485142,0.05167482,0.01674313,0.003563226,0.008388692,0.000243994,0.001598837,0.00995768,0.009681073,0.8905305,0.0000785915],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01628204,0.9723799,0.0007987148,0.00255149,0.0002105322,0.0001035205,0.0002165859,0.00004044805,0.007416742],"genre_scores_gemma":[0.1872756,0.8033195,0.002509131,0.003384714,0.0005035741,0.0002720211,0.000541022,0.00001454846,0.00217974],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001750299,"threshold_uncertainty_score":0.005855322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0922318840725777,"score_gpt":0.4391516797996283,"score_spread":0.3469197957270506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}