{"id":"W4388461381","doi":"10.1016/j.ctrv.2023.102653","title":"Pharmacotherapy for leptomeningeal disease in breast cancer","year":2023,"lang":"en","type":"article","venue":"Cancer Treatment Reviews","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"Seagen","keywords":"Medicine; Breast cancer; Trastuzumab; Clinical trial; Oncology; Metastatic breast cancer; Systemic therapy; Cancer; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001515382,0.0002737439,0.0006199912,0.0001248987,0.00005901895,0.00001323915,0.00005227534,0.00002942383,0.0009459057],"category_scores_gemma":[0.000004366712,0.0001758546,0.0003228172,0.0004115652,0.00002809777,0.00005149366,0.000009800124,0.00004601581,0.00009253776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007331359,"about_ca_system_score_gemma":0.0002136491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004408695,"about_ca_topic_score_gemma":0.00008921087,"domain_scores_codex":[0.9987198,0.00005478062,0.0003252972,0.0003995241,0.0001198979,0.0003806813],"domain_scores_gemma":[0.9993049,0.00004410367,0.00009162577,0.0002687423,0.00002887927,0.0002617876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007218376,0.0005235433,0.1546018,0.0004317531,0.000289083,0.0001081937,0.0001914615,0.000073051,0.0003143275,0.00002788781,0.0174497,0.8252673],"study_design_scores_gemma":[0.008547332,0.0002315832,0.05537044,0.000706737,0.0007435921,0.000005324221,0.00001492402,0.0003955298,0.0003593006,0.00003549567,0.9333889,0.0002008454],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.4093122,0.5413665,0.00006496248,0.03296001,0.001019963,0.01185587,0.002779857,0.0003025332,0.0003381495],"genre_scores_gemma":[0.1163811,0.8481423,0.0004326083,0.002290112,0.0008257448,0.0257941,0.0004820864,0.00008993137,0.005561974],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9159392,"threshold_uncertainty_score":0.9999673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0922318840725777,"score_gpt":0.4391516797996283,"score_spread":0.3469197957270506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}