{"id":"W4388461915","doi":"10.1016/j.isci.2023.108412","title":"Amyloid-β1-42 oligomers enhance mGlu5R-dependent synaptic weakening via NMDAR activation and complement C5aR1 signaling","year":2023,"lang":"en","type":"article","venue":"iScience","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"C.R. Younger Foundation; Reiss Family Foundation; Multiple Sclerosis Society of Canada; Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; Canadian Institutes of Health Research","keywords":"Neuroscience; NMDA receptor; Hippocampal formation; Glutamate receptor; Metabotropic glutamate receptor; Neurodegeneration; Complement system; Synaptic plasticity; Chemistry; Long-term depression; Amyloid (mycology); Receptor; Biology; AMPA receptor; Medicine; Biochemistry; Immunology; Disease; Internal medicine; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009401901,0.0002278564,0.0002108177,0.0004289276,0.001124503,0.0002226445,0.000814122,0.00004868786,0.00009821449],"category_scores_gemma":[0.0006107015,0.000213155,0.0000470934,0.002135172,0.0008947522,0.0007676571,0.0005414048,0.0003867257,0.000339438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007096031,"about_ca_system_score_gemma":0.0001073907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001945764,"about_ca_topic_score_gemma":0.000003907354,"domain_scores_codex":[0.9960821,0.0002681579,0.0003288145,0.001200769,0.001119948,0.001000182],"domain_scores_gemma":[0.9984819,0.0007452724,0.0001388333,0.0003154677,0.00005368451,0.0002648149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002284198,0.00003538895,0.0003523077,0.00001690067,0.000001644094,0.00009638162,0.0004213999,0.0004924076,0.9942668,0.0001441575,0.00009917848,0.004050605],"study_design_scores_gemma":[0.000263203,0.0001936164,0.001084383,0.00002632067,0.000005144598,0.00004672892,0.000176889,0.01405491,0.9830369,0.0002474316,0.0006374681,0.000226954],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955131,0.00002301806,0.001381622,0.001466317,0.0005421654,0.0004395656,0.000008028755,0.0002403182,0.0003859121],"genre_scores_gemma":[0.9975225,0.0001706348,0.00005224107,0.001559327,0.00006417218,0.00005954485,5.860233e-7,0.00002183424,0.000549147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01356251,"threshold_uncertainty_score":0.869221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07170257038988527,"score_gpt":0.3669046954958699,"score_spread":0.2952021251059846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}